LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction

Jay Penney; Kazuya Tsurudome; Edward H. Liao; Grant Kauwe; Lindsay Gray; Akiko Yanagiya; Mario R. Calderon; Nahum Sonenberg; A. Pejmun Haghighi

doi:10.1038/ncomms12188

Nature Communications (Jul 2016)

LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction

Jay Penney,
Kazuya Tsurudome,
Edward H. Liao,
Grant Kauwe,
Lindsay Gray,
Akiko Yanagiya,
Mario R. Calderon,
Nahum Sonenberg,
A. Pejmun Haghighi

Affiliations

Jay Penney: Department of Physiology, McGill University
Kazuya Tsurudome: Department of Physiology, McGill University
Edward H. Liao: Department of Physiology, McGill University
Grant Kauwe: Buck Institute for Research on Aging
Lindsay Gray: Buck Institute for Research on Aging
Akiko Yanagiya: Department of Biochemistry, Goodman Cancer Research Centre, McGill University, McGill University
Mario R. Calderon: Department of Physiology, McGill University
Nahum Sonenberg: Department of Biochemistry, Goodman Cancer Research Centre, McGill University, McGill University
A. Pejmun Haghighi: Department of Physiology, McGill University

DOI: https://doi.org/10.1038/ncomms12188
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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Mutations in the protein LRRK2 have been associated with Parkinson's disease but little is still known about the basic functions of the protein in the brain. Here the authors show that in fruit flies, LRRK2 regulates retrograde homeostatic synaptic compensation at the larval neuromuscular junction.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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