Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry (Dec 2019)
Synthesis and Preliminary Evaluation of Several Chalcone Derivatives as Sunscreen Compounds
Abstract
Four chalcone derivatives were synthesized and pre-evaluated as broad-spectrum UV protector. Chalcones 1-4 showed a wide range of UV absorbance values and moderate molar absorptivity values. Chalcones 3 and 4 showed better photostability than chalcones 1 and 2 because the lowering of their absorbance was smaller and slower under UVB irradiation. A combination of the spectra of chalcone derivatives 1-4 indicated that a formulation containing all four will provide a broad-spectrum sunscreen protecting the skin from UVA and UVB.
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