mBio
(Apr 2021)
Development of Spike Receptor-Binding Domain Nanoparticles as a Vaccine Candidate against SARS-CoV-2 Infection in Ferrets
Young-Il Kim,
Dokyun Kim,
Kwang-Min Yu,
Hogyu David Seo,
Shin-Ae Lee,
Mark Anthony B. Casel,
Seung-Gyu Jang,
Stephanie Kim,
WooRam Jung,
Chih-Jen Lai,
Young Ki Choi,
Jae U. Jung
Affiliations
Young-Il Kim
ORCiD College of Medicine, Chungbuk National University, Cheongju, Republic of Korea
Dokyun Kim
ORCiD Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Kwang-Min Yu
ORCiD College of Medicine, Chungbuk National University, Cheongju, Republic of Korea
Hogyu David Seo
ORCiD Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Shin-Ae Lee
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Mark Anthony B. Casel
ORCiD College of Medicine, Chungbuk National University, Cheongju, Republic of Korea
Seung-Gyu Jang
ORCiD College of Medicine, Chungbuk National University, Cheongju, Republic of Korea
Stephanie Kim
ORCiD Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
WooRam Jung
ORCiD Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Chih-Jen Lai
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Young Ki Choi
ORCiD College of Medicine, Chungbuk National University, Cheongju, Republic of Korea
Jae U. Jung
ORCiD Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
DOI
https://doi.org/10.1128/mBio.00230-21
Journal volume & issue
Vol. 12,
no. 2
Abstract
Read online
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a causative agent of the CoV disease 2019 (COVID-19) pandemic, enters host cells via the interaction of its receptor-binding domain (RBD) of the spike protein with host angiotensin-converting enzyme 2 (ACE2). Therefore, the RBD is a promising vaccine target to induce protective immunity against SARS-CoV-2 infection.
WeChat QR code
Close
