Development of Spike Receptor-Binding Domain Nanoparticles as a Vaccine Candidate against SARS-CoV-2 Infection in Ferrets

Young-Il Kim; Dokyun Kim; Kwang-Min Yu; Hogyu David Seo; Shin-Ae Lee; Mark Anthony B. Casel; Seung-Gyu Jang; Stephanie Kim; WooRam Jung; Chih-Jen Lai; Young Ki Choi; Jae U. Jung

doi:10.1128/mBio.00230-21

mBio (Apr 2021)

Development of Spike Receptor-Binding Domain Nanoparticles as a Vaccine Candidate against SARS-CoV-2 Infection in Ferrets

Young-Il Kim,
Dokyun Kim,
Kwang-Min Yu,
Hogyu David Seo,
Shin-Ae Lee,
Mark Anthony B. Casel,
Seung-Gyu Jang,
Stephanie Kim,
WooRam Jung,
Chih-Jen Lai,
Young Ki Choi,
Jae U. Jung

Affiliations

Young-Il Kim: ORCiD; College of Medicine, Chungbuk National University, Cheongju, Republic of Korea
Dokyun Kim: ORCiD; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Kwang-Min Yu: ORCiD; College of Medicine, Chungbuk National University, Cheongju, Republic of Korea
Hogyu David Seo: ORCiD; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Shin-Ae Lee: Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Mark Anthony B. Casel: ORCiD; College of Medicine, Chungbuk National University, Cheongju, Republic of Korea
Seung-Gyu Jang: ORCiD; College of Medicine, Chungbuk National University, Cheongju, Republic of Korea
Stephanie Kim: ORCiD; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
WooRam Jung: ORCiD; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Chih-Jen Lai: Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Young Ki Choi: ORCiD; College of Medicine, Chungbuk National University, Cheongju, Republic of Korea
Jae U. Jung: ORCiD; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

DOI: https://doi.org/10.1128/mBio.00230-21
Journal volume & issue: Vol. 12, no. 2

Abstract

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a causative agent of the CoV disease 2019 (COVID-19) pandemic, enters host cells via the interaction of its receptor-binding domain (RBD) of the spike protein with host angiotensin-converting enzyme 2 (ACE2). Therefore, the RBD is a promising vaccine target to induce protective immunity against SARS-CoV-2 infection.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal