Nature Communications (Nov 2022)
SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks
- Priya Kapoor-Vazirani,
- Sandip K. Rath,
- Xu Liu,
- Zhen Shu,
- Nicole E. Bowen,
- Yitong Chen,
- Ramona Haji-Seyed-Javadi,
- Waaqo Daddacha,
- Elizabeth V. Minten,
- Diana Danelia,
- Daniela Farchi,
- Duc M. Duong,
- Nicholas T. Seyfried,
- Xingming Deng,
- Eric A. Ortlund,
- Baek Kim,
- David S. Yu
Affiliations
- Priya Kapoor-Vazirani
- Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine
- Sandip K. Rath
- Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine
- Xu Liu
- Department of Biochemistry, Emory University School of Medicine
- Zhen Shu
- Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine
- Nicole E. Bowen
- Department of Pediatrics, Emory University School of Medicine
- Yitong Chen
- Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine
- Ramona Haji-Seyed-Javadi
- Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine
- Waaqo Daddacha
- Department of Biochemistry and Molecular Biology, Medical College of Georgia at Augusta University
- Elizabeth V. Minten
- Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine
- Diana Danelia
- Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine
- Daniela Farchi
- Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine
- Duc M. Duong
- Department of Biochemistry, Emory University School of Medicine
- Nicholas T. Seyfried
- Department of Biochemistry, Emory University School of Medicine
- Xingming Deng
- Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine
- Eric A. Ortlund
- Department of Biochemistry, Emory University School of Medicine
- Baek Kim
- Department of Pediatrics, Emory University School of Medicine
- David S. Yu
- Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-34578-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
SAMHD1 has a dNTPase-independent resection function in genome maintenance. Here the authors show that SAMHD1 is deacetylated at conserved K354 by SIRT1 to facilitate direct binding with ssDNA to promote DNA end resection and homologous recombination.
