Scientific Reports (Jan 2021)

Formulation and in vitro evaluation of self-nanoemulsifying liquisolid tablets of furosemide

  • Lena Dalal,
  • Abdul Wahab Allaf,
  • Hind El-Zein

DOI
https://doi.org/10.1038/s41598-020-79940-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 10

Abstract

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Abstract Self-nanoemulsifying drug delivery systems (SNEDDS) were used to enhance the dissolution rate of furosemide as a model for class IV drugs and the system was solidified into liquisolid tablets. SNEDDS of furosemide contained 10% Castor oil, 60% Cremophor EL, and 30% PEG 400. The mean droplets size was 17.9 ± 4.5 nm. The theoretical model was used to calculate the amounts of the carrier (Avicel PH101) and coating materials (Aerosil 200) to prepare liquisolid powder. Carrier/coating materials ratio of 5/1 was used and Ludipress was added to the solid system, thus tablets with hardness of 45 ± 2 N were obtained. Liquisolid tablets showed 2-folds increase in drug release as compared to the generic tablets after 60 min in HCl 0.1 N using USP apparatus-II. Furosemide loaded SNEDDS tablets have great prospects for further in vivo studies, and the theoretical model is useful for calculating the adequate amounts of adsorbents required to solidify these systems.