Exploratory Animal and Medical Research (Jun 2013)
ANTI-ULCER ACTIVITY OF SHANKHA BHASMA (CALCINED CONCH-SHELL)
Abstract
The anti-ulcer activities along with chemical identification of purified Shankha Bhasma (SBM) or calcined conch-shell was undertaken. Shankha Bhasma (SBM) was prepared by traditional process used in India. The chemical composition of SBM was studied by atomic absorption spectrometry and infra-red spectral analysis. Acute oral toxicity of SBM was done in Swiss mice. SBM (25 mg/kg and 50 mg/kg) was studied for anti-ulcer effect on ethanol induced and pylorus ligature induced model in Wistar rats. SBM showed significant (P<0.001) positive results in both the models in comparison with respective control and standard control (omeprazole 20 mg/kg and ranitidine 50 mg/kg).
