Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells

Xiao-Ping Liu; Karl R. Koehler; Andrew M. Mikosz; Eri Hashino; Jeffrey R. Holt

doi:10.1038/ncomms11508

Nature Communications (May 2016)

Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells

Xiao-Ping Liu,
Karl R. Koehler,
Andrew M. Mikosz,
Eri Hashino,
Jeffrey R. Holt

Affiliations

Xiao-Ping Liu: Department of Otolaryngology, F.M. Kirby Neurobiology Center Boston Children’s Hospital, and Harvard Medical School
Karl R. Koehler: Department of Otolaryngology-Head and Neck Surgery and Stark Neurosciences Research Institute, Indiana University School of Medicine
Andrew M. Mikosz: Department of Otolaryngology-Head and Neck Surgery and Stark Neurosciences Research Institute, Indiana University School of Medicine
Eri Hashino: Department of Otolaryngology-Head and Neck Surgery and Stark Neurosciences Research Institute, Indiana University School of Medicine
Jeffrey R. Holt: Department of Otolaryngology, F.M. Kirby Neurobiology Center Boston Children’s Hospital, and Harvard Medical School

DOI: https://doi.org/10.1038/ncomms11508
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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Sensory hair cells from the mammalian inner ear do not regenerate. Here, the authors induce direct hair cell formation from mouse embryonic stem cells using a three-dimensional culture system and observe differentiation of Type I and Type II vestibular hair cells and establishment of synapses with neurons.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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