Pharmacokinetics of antisense oligonucleotide drugs

Abstract

This review covers the pharmacokinetic characteristics of the various antisense oligonucleotide drugs. A comparison of the pharmacokinetics of drugs first and second generation. As well as the influence on the pharmacokinetics of the chemical modification of the molecule.

Keywords

• антисмысловые олигонуклеотиды
• фосфотиоатные олигодеоксинуклеотиды
• фармакокинетика
• antisense oligonucleotides
• phosphorothioate oligodeoxynucleotides
• pharmacokinetics