Erythropoietin promotes hippocampal mitochondrial function and enhances cognition in mice

Robert A. Jacobs; Mostafa A. Aboouf; Christina Koester-Hegmann; Paola Muttathukunnel; Sofien Laouafa; Christian Arias-Reyes; Markus Thiersch; Jorge Soliz; Max Gassmann; Edith M. Schneider Gasser

doi:10.1038/s42003-021-02465-8

Communications Biology (Aug 2021)

Erythropoietin promotes hippocampal mitochondrial function and enhances cognition in mice

Robert A. Jacobs,
Mostafa A. Aboouf,
Christina Koester-Hegmann,
Paola Muttathukunnel,
Sofien Laouafa,
Christian Arias-Reyes,
Markus Thiersch,
Jorge Soliz,
Max Gassmann,
Edith M. Schneider Gasser

Affiliations

Robert A. Jacobs: Institute of Veterinary Physiology, Vetsuisse-Faculty, University of Zurich
Mostafa A. Aboouf: Institute of Veterinary Physiology, Vetsuisse-Faculty, University of Zurich
Christina Koester-Hegmann: Institute of Veterinary Physiology, Vetsuisse-Faculty, University of Zurich
Paola Muttathukunnel: Institute of Pharmacology and Toxicology, University of Zurich
Sofien Laouafa: Faculty of Medicine, Centre Hospitalier Universitaire de Québec (CHUQ), Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval
Christian Arias-Reyes: Faculty of Medicine, Centre Hospitalier Universitaire de Québec (CHUQ), Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval
Markus Thiersch: Institute of Veterinary Physiology, Vetsuisse-Faculty, University of Zurich
Jorge Soliz: Faculty of Medicine, Centre Hospitalier Universitaire de Québec (CHUQ), Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval
Max Gassmann: Institute of Veterinary Physiology, Vetsuisse-Faculty, University of Zurich
Edith M. Schneider Gasser: Institute of Veterinary Physiology, Vetsuisse-Faculty, University of Zurich

DOI: https://doi.org/10.1038/s42003-021-02465-8
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 19

Abstract

Read online

Robert Jacobs, Mostafa Aboouf, et al. examined the effect of erythropoietin (EPO) in hippocampal mitochondrial function and memory in two mouse models: one overexpressing EPO in the brain, and juvenile mice treated during three days with a high dose of intraperitoneal EPO. Their results suggest that erythropoietin in the neonatal brain may impact spatial memory by increasing mitochondrial content.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal