Malondialdehyde in benign prostate hypertrophy: a useful marker?

Rosaria Alba Merendino; Francesco Salvo; Antonella Saija; Giuseppe Di Pasquale; Antonio Tomaino; Paola Lucia Minciullo; Giuseppe Fraccica; Sebastiano Gangemi

doi:10.1080/0962935031000097745

Mediators of Inflammation (Jan 2003)

Malondialdehyde in benign prostate hypertrophy: a useful marker?

Rosaria Alba Merendino,
Francesco Salvo,
Antonella Saija,
Giuseppe Di Pasquale,
Antonio Tomaino,
Paola Lucia Minciullo,
Giuseppe Fraccica,
Sebastiano Gangemi

Affiliations

Rosaria Alba Merendino: Chair of Immunopathology, Department of Human Pathology, University of Messina Medical School, University Hospital G. Martino, Via Centonze n° 200, is. 98, Messina 98123, Italy
Francesco Salvo: School and Division of Urology, Department of Human Pathology, University of Messina Medical School, University Hospital G. Martino, Via Centonze n° 200, is. 98, Messina 98123, Italy
Antonella Saija: School of Pharmacy, Department Farmaco-Biologico, University of Messina Medical School, University Hospital G. Martino, Via Centonze n° 200, is. 98, Messina 98123, Italy
Giuseppe Di Pasquale: Department of Internal Medicine, University of Messina Medical School, University Hospital G. Martino, Via Centonze n° 200, is. 98, Messina 98123, Italy
Antonio Tomaino: School of Pharmacy, Department Farmaco-Biologico, University of Messina Medical School, University Hospital G. Martino, Via Centonze n° 200, is. 98, Messina 98123, Italy
Paola Lucia Minciullo: School and Division of Allergy and Clinical Immunology, Department of Human Pathology, University of Messina Medical School, University Hospital G. Martino, Via Centonze n° 200, is. 98, Messina 98123, Italy
Giuseppe Fraccica: School and Division of Urology, Department of Human Pathology, University of Messina Medical School, University Hospital G. Martino, Via Centonze n° 200, is. 98, Messina 98123, Italy
Sebastiano Gangemi: School and Division of Allergy and Clinical Immunology, Department of Human Pathology, University of Messina Medical School, University Hospital G. Martino, Via Centonze n° 200, is. 98, Messina 98123, Italy

DOI: https://doi.org/10.1080/0962935031000097745
Journal volume & issue: Vol. 12, no. 2
pp. 127 – 128

Abstract

Read online

Benign prostate hypertrophy (BPH) is the most common benign tumor in men due to obstruction of the urethra and, finally, uremia. Malondialdehyde (MDA) is a product derived from peroxidation of polyunsaturated fatty acids and related esters. Evaluation of MDA in serum represents a non-invasive biomarker of oxidative stress. Prostate-specific antigen (PSA) is a sensitive marker for prostatic hypertrophy and cancer. We analyzed MDA serum levels to evaluate the oxidative stress in BPH. To this end, 22 BPH patients and 22 healthy donors were enrolled. Data show an increase of MDA level in BPH patients and a positive correlation between PSA and MDA levels. In conclusion, we describe a previously unknown relationship between PSA and MDA as an index of inflammation and oxidative stress in BPH.

Published in Mediators of Inflammation

ISSN: 0962-9351 (Print); 1466-1861 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Pathology
Website: https://onlinelibrary.wiley.com/journal/4792

About the journal

Abstract

Keywords