Liver and Inflammatory Biomarkers Are Related to High Mortality in Hospitalized Patients with COVID-19 in Brazilian Amazon Region
Carla Sousa da Silva,
Katrini Guidolini Martinelli,
Marlison Wesley Miranda Viana,
Deliane dos Santos Soares,
Yasmin Garcia Silva Corrêa,
Lucas Lima da Silva,
Vanessa Salete de Paula,
Luana Lorena Silva Rodrigues,
Livia Melo Villar
Affiliations
Carla Sousa da Silva
Programa de Pós-Graduação em Ciências da Saúde, Instituto de Saúde Coletiva, Universidade Federal do Oeste do Pará (UFOPA), Santarém 66075-110, Brazil
Katrini Guidolini Martinelli
Departamento de Medicina Social, Universidade Federal do Espírito Santo (UFES), Vitória 29040-090, Brazil
Marlison Wesley Miranda Viana
Curso de Enfermagem, Universidade da Amazônia (UNAMA) Campus Santarém, Santarém 68010-200, Brazil
Deliane dos Santos Soares
Residência Multiprofissional em Estratégia Saúde da Família para as Populações do Baixo Amazonas, Instituto de Saúde Coletiva, Universidade Federal do Oeste do Pará (UFOPA), Santarém 66075-110, Brazil
Yasmin Garcia Silva Corrêa
Instituto de Biodiversidade e Florestas, Universidade Federal do Oeste do Pará (UFOPA), Santarém 66075-110, Brazil
Lucas Lima da Silva
Laboratório de Hepatites Virais, Instituto Oswaldo Cruz (IOC/Fiocruz), Rio de Janeiro 21040-360, Brazil
Vanessa Salete de Paula
Laboratório de Virologia e Parasitologia Molecular, Instituto Oswaldo Cruz (IOC/Fiocruz), Rio de Janeiro 21040-360, Brazil
Luana Lorena Silva Rodrigues
Programa de Pós-Graduação em Ciências da Saúde, Instituto de Saúde Coletiva, Universidade Federal do Oeste do Pará (UFOPA), Santarém 66075-110, Brazil
Livia Melo Villar
Laboratório de Hepatites Virais, Instituto Oswaldo Cruz (IOC/Fiocruz), Rio de Janeiro 21040-360, Brazil
COVID-19 is a multisystem disease with many clinical manifestations, including liver damage and inflammation. The objective of this study is to analyze inflammation biomarkers in relation to the clinical outcome and respiratory symptoms of COVID-19. This is a retrospective cohort of patients with COVID-19 admitted to the Hospital Regional do Baixo Amazonas from 2020 to 2022. Data were collected from electronic medical records from admission to the 30th day of hospitalization and soon after hospital discharge. A total of 397 patients were included in the study. In the longitudinal follow-up of liver markers, a significant difference was found for AST on day 14, with a higher median in the death group. Among the hematological markers, lymphopenia was observed throughout the follow-up, with the death group having the most altered values. When comparing the evolution of biomarkers in the Non-Invasive Ventilation (NIV) and Invasive Mechanical Ventilation (IMV) groups, AST showed a significant difference only on day 14 and GGT on day 1, being greater in the IMV group, and indirect bilirubin on day 7 being more altered in the NIV group. In conclusion, death during hospitalization or a more severe form of COVID-19 was related to significant changes in liver and inflammatory biomarkers.