Biomedicines (Oct 2021)

Pre-Existing Humoral Immunological Memory Is Retained in Patients with Multiple Sclerosis Receiving Cladribine Therapy

  • Tobias Moser,
  • Ciara O’Sullivan,
  • Christian Puttinger,
  • Julia Feige,
  • Georg Pilz,
  • Elisabeth Haschke-Becher,
  • Janne Cadamuro,
  • Hannes Oberkofler,
  • Wolfgang Hitzl,
  • Andrea Harrer,
  • Jörg Kraus,
  • Eugen Trinka,
  • Peter Wipfler

DOI
https://doi.org/10.3390/biomedicines9111584
Journal volume & issue
Vol. 9, no. 11
p. 1584

Abstract

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Cladribine (CLAD) is a lymphodepleting agent approved for active relapsing multiple sclerosis (MS). The impact of CLAD on the adaptive humoral immune system has not sufficiently been studied. This study aimed to assess the influence of CLAD treatment on specific antibody titers to common pathogens. We included 18 MS patients treated with CLAD. Serum IgG antibody levels to measles, mumps, rubella, hepatitis B and varicella zoster virus (VZV), as well as diphtheria and tetanus toxins, were measured prior to the initiation of treatment and at 12 and 24 months after first CLAD administration. Moreover, specimens were longitudinally analyzed regarding absolute blood concentrations of IgG and main lymphocyte subsets. No reduction in antibody levels against measles, mumps, rubella, VZV, hepatitis B, diphtheria toxin and tetanus toxin associated with CLAD treatment was observed. Loss of seroprotection occurred in p p < 0.000001). This study suggests that CLAD does not interfere with the pre-existing humoral immunologic memory in terms of pathogen-specific antibody titers.

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