The role of innate immunity in the formation of various variants of the course of seasonal allergic rhinitis

Abstract

Purpose: to study the functional parameters of the innate immune response in various clinical courses of seasonal allergic rhinitis.Materials and methods: a comparative prospective study was conducted. 62 participants (patients with seasonal allergic rhinitis) were divided into subgroups with mild (34 people) and moderate (28 people). Th e parameters of the innate immune response were studied. Th e assessment was carried out during the exacerbation period, before the appointment of therapy and in remission, outside the palination season.Results: changes in the cells of the innate immune response in patients with seasonal allergic rhinitis are formed at the earliest stages of clinical manifestation, aff ect the functional potential of natural killer cells and the oxygen-producing activity of the neutrophilic link, and are stable outside the palination season. Increased production of proinfl ammatory and immunoregulatory mediators is a key manifestation of the progression of seasonal allergic rhinitis.Conclusion: inhibition of the functional resources of innate immunity cells and cytokine dysregulation can play a significant role in the development of complications of seasonal allergic rhinitis caused by secondary immune defi ciency.

Keywords

• seasonal allergic rhinitis
• innate immunity
• cytokines financing