Discovery of Novel Diterpenoids from Sinularia arborea
Kuan-Hua Chen,
Chang-Feng Dai,
Tsong-Long Hwang,
Chun-Yu Chen,
Jan-Jung Li,
Jih-Jung Chen,
Yang-Chang Wu,
Jyh-Horng Sheu,
Wei-Hsien Wang,
Ping-Jyun Sung
Affiliations
Kuan-Hua Chen
Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
Chang-Feng Dai
Institute of Oceanography, National Taiwan University, Taipei 106, Taiwan
Tsong-Long Hwang
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
Chun-Yu Chen
Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
Jan-Jung Li
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Jih-Jung Chen
Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan
Yang-Chang Wu
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Jyh-Horng Sheu
Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Wei-Hsien Wang
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Ping-Jyun Sung
Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
Two novel diterpenoids, sinularbols A (1) and B (2), which were found to possess a new carbon skeleton were isolated from the soft coral Sinularia arborea. The structures of compounds 1 and 2 were elucidated by spectroscopic methods and 2 displayed a moderately inhibitory effect on the generation of superoxide anion by human neutrophils.
