Nature Communications (Feb 2020)

DNA unwinding mechanism of a eukaryotic replicative CMG helicase

  • Zuanning Yuan,
  • Roxana Georgescu,
  • Lin Bai,
  • Dan Zhang,
  • Huilin Li,
  • Michael E. O’Donnell

DOI
https://doi.org/10.1038/s41467-020-14577-6
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 10

Abstract

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The DNA duplex is known to be split apart in a steric exclusion manner during replication, but the specific mechanism has remained unclear. Here the authors present a cryo-EM structure of a eukaryotic replicative CMG helicase on forked DNA, revealing the mechanism of DNA unwinding.