Nature Communications (May 2020)
Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma
- Nayoung Kim,
- Hong Kwan Kim,
- Kyungjong Lee,
- Yourae Hong,
- Jong Ho Cho,
- Jung Won Choi,
- Jung-Il Lee,
- Yeon-Lim Suh,
- Bo Mi Ku,
- Hye Hyeon Eum,
- Soyean Choi,
- Yoon-La Choi,
- Je-Gun Joung,
- Woong-Yang Park,
- Hyun Ae Jung,
- Jong-Mu Sun,
- Se-Hoon Lee,
- Jin Seok Ahn,
- Keunchil Park,
- Myung-Ju Ahn,
- Hae-Ock Lee
Affiliations
- Nayoung Kim
- Samsung Genome Institute, Samsung Medical Center
- Hong Kwan Kim
- Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Kyungjong Lee
- Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Yourae Hong
- Samsung Genome Institute, Samsung Medical Center
- Jong Ho Cho
- Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Jung Won Choi
- Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Jung-Il Lee
- Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Yeon-Lim Suh
- Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Bo Mi Ku
- Samsung Biomedical Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Hye Hyeon Eum
- Samsung Genome Institute, Samsung Medical Center
- Soyean Choi
- Samsung Genome Institute, Samsung Medical Center
- Yoon-La Choi
- Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences &Technology, Sungkyunkwan University
- Je-Gun Joung
- Samsung Genome Institute, Samsung Medical Center
- Woong-Yang Park
- Samsung Genome Institute, Samsung Medical Center
- Hyun Ae Jung
- Division of Haematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Jong-Mu Sun
- Division of Haematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Se-Hoon Lee
- Division of Haematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Jin Seok Ahn
- Division of Haematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Keunchil Park
- Division of Haematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Myung-Ju Ahn
- Division of Haematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine
- Hae-Ock Lee
- Samsung Genome Institute, Samsung Medical Center
- DOI
- https://doi.org/10.1038/s41467-020-16164-1
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Understanding the mechanisms that lead to lung adenocarcinoma metastasis is important for identifying new therapeutics. Here, the authors document the changes in the transcriptome of human lung adenocarcinoma using single-cell sequencing and link cancer cell signatures to immune cell dynamics.
