Notoginsenoside R1 attenuates sevoflurane-induced neurotoxicity

Abstract

Sevoflurane, a volatile anesthetic, is known to induce widespread neuronal degeneration and apoptosis. Recently, the stress-inducible protein sestrin 2 and adenosine monophosphate-activated protein kinase (AMPK) have been found to regulate the levels of intracellular reactive oxygen species (ROS) and suppress oxidative stress. Notoginsenoside R1 (NGR1), a saponin isolated from Panax notoginseng, has been shown to exert neuroprotective effects. The effects of NGR1 against neurotoxicity induced by sevoflurane were assessed.

Keywords

• 5′-amp-activated protein kinase
• neurotoxicity
• notoginsenoside r1
• sevoflurane
• sestrin-2
• reactive oxygen species