Nature Communications (Dec 2019)

Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect

  • Aoxing Cheng,
  • Peng Zhang,
  • Bo Wang,
  • Dongdong Yang,
  • Xiaotao Duan,
  • Yongliang Jiang,
  • Tian Xu,
  • Ya Jiang,
  • Jiahui Shi,
  • Chengtao Ding,
  • Gao Wu,
  • Zhihong Sang,
  • Qiang Wu,
  • Hua Wang,
  • Mian Wu,
  • Zhiyong Zhang,
  • Xin Pan,
  • Yue-yin Pan,
  • Ping Gao,
  • Huafeng Zhang,
  • Cong-zhao Zhou,
  • Jing Guo,
  • Zhenye Yang

DOI
https://doi.org/10.1038/s41467-019-13485-8
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 16

Abstract

Read online

Aurora-A kinase is frequently over-expressed in tumours. Here, the authors show that it modulates the activity of lactate dehydrogenase B, resulting in enhanced glycolysis, bio-synthesis and tumour growth.