Comparative cross-sectional study of Interferon Gamma inducible protein-10 in mono and co-infected human Immunodeficiency Virus patients in Alexandria, Egypt

Abstract

Background: Humanimmunodeficiencyvirus (HIV) infection is a global health issue. Upon invasion, the virus induces many inflammatory cytokines; especially interferon-γ induced protein 10 (IP-10). The aim of our study was to detect and compare the serum IP- 10 levels in HIV mono- infected, hepatitis C virus (HCV) mono- infected patients, and HIV co-infected patients with HCV. Methods: The study included 30 HIV patients (15 mono- infected and 15 co-infected with HCV), 15 HCV infected patients and15 healthy controls. HIV RNA, HCV RNA, CD4+T cell counts, IP-10 levels and Fibrous -4 score were estimated. Results: The mean value for HIV PCR was 1.04*104 ± 3.86*104 in HIV co-infected patients and 4.14*107 ± 1.58*108 in HIV mono-infected patients. The highest mean value for FIB-4 scores and CD4+T cell counts were among HIV co-infected patients; 1.56 ± 2.17 and 432.80 ± 294.83 respectively. HCV mono-infected patients revealed the highest IP-10 mean value; 472.0±235.28. No significant difference was found in HIV co-infected (p = 0.806, 0.327) nor HIV mono-infected patients (p =0.244,0.581) regarding the relation between CD4+T counts 5(> 400 or < 400) with the IP-10 levels and FIB-4 scores respectively. Conclusions: High IP-10 levels were associated with low CD4 cell count in HIV mono and co-infected patients. IP-10 secretion may be related to HIV pathogenesis and immune depletion. HIV/HCV co-infection did not influence HIV disease progression.

Keywords

• cd4+t cell
• co-infection
• highly active antiretroviral therapy
• human immunodeficiency virus
• interferon-γ induced protein- 10