Determining the influence of endoskeleton friction on the damping of pulsating antibubbles

Abstract

Recent in-vivo work showed the suitability of Pickering-stabilized antibubbles in harmonic imaging and ultrasound-guided drug delivery. To date, however, theoretical considerations of antibubble core properties and their effects on antibubble dynamics have been rather sparse. The purpose of this study was to investigate the influence of skeletal friction on the damping of a pulsating antibubble and the pulsation phase of an antibubble relative to the incident sound wave. Numerical simulations were performed to compute damping terms and pulsation phases of micron-sized antibubbles with thin elastic shells and 30% endoskeleton volume fraction. The simulations showed that the damping owing to skeleton presence dominates the damping mechanism for antibubbles of radii less than 2.5 μm, whilst it is negligible for greater radii. The pulsation phase of such small antibubbles was simulated to have a phase delay of up to 1/6 π with respect to pulsating free gas bubbles. Our findings demonstrate that the presence of an endoskeleton inside a bubble influences pulsation phase and damping of small antibubbles. Antibubbles of radii less than 3 μm are of interest for the use as ultrasound contrast agents.

Keywords

• acoustic driving
• ultrasound contrast agent
• endoskeleton
• antibubble damping modelling
• harmonic oscillation