Nature Communications (Apr 2018)

Dynamic tuneable G protein-coupled receptor monomer-dimer populations

  • Patricia M. Dijkman,
  • Oliver K. Castell,
  • Alan D. Goddard,
  • Juan C. Munoz-Garcia,
  • Chris de Graaf,
  • Mark I. Wallace,
  • Anthony Watts

DOI
https://doi.org/10.1038/s41467-018-03727-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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Evidence suggests oligomerisation of G protein-coupled receptors in membranes, but this is controversial. Here, authors use single-molecule and ensemble FRET, and spectroscopy to show that the neurotensin receptor 1 forms multiple dimer conformations that interconvert - “rolling” interfaces.