Optimal Coefficient of Variance Threshold to Minimize Hypoglycemia Risk in Individuals with Well-Controlled Type 1 Diabetes Mellitus

Abstract

Background This study investigated the optimal coefficient of variance (%CV) for preventing hypoglycemia based on real-time continuous glucose monitoring (rt-CGM) data in people with type 1 diabetes mellitus (T1DM) already achieving their mean glucose (MG) target. Methods Data from 172 subjects who underwent rt-CGM for at least 90 days and for whom 439 90-day glycemic profiles were available were analyzed. Receiver operator characteristic analysis was conducted to determine the cut-off value of %CV to achieve time below range (%TBR)135 mg/dL, and ≤135 mg/dL, respectively. The cut-off value for %TBR135 mg/dL, 99.4% of profiles with a %CV <37.3 achieved %TBR< 54mg/dL <1. Conclusion In well-controlled T1DM with MG ≤135 mg/dL, we suggest a %CV <31% to achieve the %TBR< 54mg/dL <1 target. Furthermore, we suggest a %CV <29.2% to achieve the target of %TBR< 54mg/dL =0 for people at high risk of hypoglycemia.

Keywords

• blood glucose
• blood glucose self-monitoring
• diabetes mellitus, type 1
• hypoglycemia