Chemiluminescence: From mechanism to applications in biological imaging and therapy
Zhijia Wang,
Jiaguo Huang,
Jingsheng Huang,
Bingran Yu,
Kanyi Pu,
Fu‐Jian Xu
Affiliations
Zhijia Wang
Laboratory of Biomedical Materials and Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology, Ministry of Education) Beijing University of Chemical Technology Beijing P.R. China
Jiaguo Huang
School of Chemical and Biomedical Engineering Nanyang Technological University Singapore
Jingsheng Huang
School of Chemical and Biomedical Engineering Nanyang Technological University Singapore
Bingran Yu
Laboratory of Biomedical Materials and Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology, Ministry of Education) Beijing University of Chemical Technology Beijing P.R. China
Kanyi Pu
School of Chemical and Biomedical Engineering Nanyang Technological University Singapore
Fu‐Jian Xu
Laboratory of Biomedical Materials and Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology, Ministry of Education) Beijing University of Chemical Technology Beijing P.R. China
Abstract Chemiluminescence (CL) is an emission phenomenon induced by chemical reaction. Different from the photoluminescence, CL is free from external excitation source, which is expected to show great advantages such as higher signal‐to‐background ratio (SBR) in bioimaging, and deeper tissue penetration in photodynamic therapy (PDT). This review introduces the theoretical aspects of CL mechanism, such as classification, energy consideration and chemiexcited/photoexcited states. Application of CL in bioimaging is highlighted. In particular, the approaches to modulate the brightness and the wavelength of CL are summarized, which are two fundamental parameters in bioimaging. Finally, the application of CL in PDT is introduced. The potential challenges and perspectives of CL in bioimaging and therapy are also discussed.
