Genomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species

José F. Muñoz; Lalitha Gade; Nancy A. Chow; Vladimir N. Loparev; Phalasy Juieng; Elizabeth L. Berkow; Rhys A. Farrer; Anastasia P. Litvintseva; Christina A. Cuomo

doi:10.1038/s41467-018-07779-6

Nature Communications (Dec 2018)

Genomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species

José F. Muñoz,
Lalitha Gade,
Nancy A. Chow,
Vladimir N. Loparev,
Phalasy Juieng,
Elizabeth L. Berkow,
Rhys A. Farrer,
Anastasia P. Litvintseva,
Christina A. Cuomo

Affiliations

José F. Muñoz: Broad Institute of MIT and Harvard
Lalitha Gade: Mycotic Diseases Branch, Centers for Disease Control and Prevention
Nancy A. Chow: Mycotic Diseases Branch, Centers for Disease Control and Prevention
Vladimir N. Loparev: Biotechnology Core Facility Branch, Centers for Disease Control and Prevention
Phalasy Juieng: Biotechnology Core Facility Branch, Centers for Disease Control and Prevention
Elizabeth L. Berkow: Mycotic Diseases Branch, Centers for Disease Control and Prevention
Rhys A. Farrer: Broad Institute of MIT and Harvard
Anastasia P. Litvintseva: Mycotic Diseases Branch, Centers for Disease Control and Prevention
Christina A. Cuomo: Broad Institute of MIT and Harvard

DOI: https://doi.org/10.1038/s41467-018-07779-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Candida auris is an emergent fungal pathogen that is resistant to multiple antifungals. Here, Muñoz et al. analyse genomic sequences for isolates from each of the four major C. auris clades and for three related species, and identify genetic features associated with virulence, antifungal resistance and mating.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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