Advances in the surgical treatment of Parkinson's disease

Abstract

Parkinson's disease (PD) is a complex, chronic and progressive neurodegenerative disease. When medication doesn't work well, surgical treatments should be considered to improve symptoms. Currently, surgical treatments to PD include not only neurosurgical ablation with different principles, such as radiofrequency ablation (RFA), magnetic resonance guided laser interstitial thermal therapy (MRgLITT), magnetic resonance guided focused ultrasound (MRgFUS) and stereotactic radiotherapy (SRT), but also neuromodulation techniques including deep brain stimulation (DBS). In addition, spinal cord stimulation (SCS), gene and transplantation therapy to PD are also being explored. This review focuses on advances of above treatments of PD, and analyzes their efficacy and safety in order to provide more theory and basis for clinical researchs.

Keywords

• parkinson disease
• denervation
• deep brain stimulation
• neurosurgical procedures
• review