Communications Biology (Mar 2023)

Release of frustration drives corneal amyloid disaggregation by brain chaperone

  • Jia Yi Kimberly Low,
  • Xiangyan Shi,
  • Venkatraman Anandalakshmi,
  • Dawn Neo,
  • Gary Swee Lim Peh,
  • Siew Kwan Koh,
  • Lei Zhou,
  • M. K. Abdul Rahim,
  • Ketti Boo,
  • JiaXuan Lee,
  • Harini Mohanram,
  • Reema Alag,
  • Yuguang Mu,
  • Jodhbir S. Mehta,
  • Konstantin Pervushin

DOI
https://doi.org/10.1038/s42003-023-04725-1
Journal volume & issue
Vol. 6, no. 1
pp. 1 – 12

Abstract

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ATP-independent amyloid-β chaperone L-PGDS disaggregates corneal amyloids in surgically excised human cornea of TGFBI-related corneal dystrophy patients by recognizing and releasing structurally frustrated regions.