Research Progress on the Analysis of Anabolic Androgenic Steroids in Biological Samples Based on High Resolution Mass Spectrometry

Abstract

Anabolic androgenic steroids （AASs） are a class of synthetic steroid hormones that mimic androgens, and they rank as the most widely abused doping agents worldwide. High resolution mass spectrometry （HRMS） has unique advantages in the detection of AASs due to its high resolution, high sensitivity, high selectivity and data traceability. HRMS can not only be used for the qualitative and quantitative analysis of AASs and their metabolites in different biological samples, effectively improving the ability to analyze complex samples and increasing the reliability of analytical results, but can also infer AASs metabolites and reveal metabolic pathways by combining in vitro and in vivo metabolic models. This paper reviews the research progress of HRMS in AASs analysis methods, in vitro and in vivo metabolism of AASs, and also explores its application prospects in the field of forensic science.

Keywords

• forensic medicine
• toxicological analysis
• high resolution mass spectrometry （hrms）
• anabolic androgenic steroid
• doping agent
• biological sample
• metabolite
• review