Comment on Villalva et al. Antioxidant, Anti-Inflammatory, and Antibacterial Properties of an <i>Achillea millefolium</i> L. Extract and Its Fractions Obtained by Supercritical Anti-Solvent Fractionation against <i>Helicobacter pylori</i>. <i>Antioxidants</i> 2022, <i>11</i>, 1849

Abstract

Villalva et al. evaluated the potential utility of an Achillea millefolium (yarrow) extract in the control of H. pylori infection. The agar-well diffusions bioassay was applied to determine the antimicrobial activity of yarrow extracts. The supercritical anti-solvent fractionation process of yarrow extract was made to give two different fractions with polar phenolic compounds and monoterpenes and sesquiterpenes, respectively. Phenolic compounds were identified by HPLC-ESIMS by using the accurate masses of [M−H]− ions and the characteristic product ions. However, some of the reported product ions seem to be disputable, as described below.

Keywords

• yarrow
• flavonoids
• fragmentation pathway
• mass spectrometry
• electrospray ionization