Epidemiological and typing features of HPV co-infections in MSM with mpox: A hospital-based prospective study

Tianyang Liu; Siwei Zhang; Liuqing Yang; Ling Peng; Shanshan Tang; Wanlin Li; Zengchen Liu; Xichao Zhu; Tingdan Gong; Siyu Duan; Yunyan Tang; Yao Wang; Yun Peng; Rui Li; Shiyan Feng; Chuming Chen; Mengli Cao; Siran Huang; Yang Yang; Fuxiang Wang; Hongzhou Lu; Lanlan Wei

Journal of Infection and Public Health (Dec 2024)

Epidemiological and typing features of HPV co-infections in MSM with mpox: A hospital-based prospective study

Tianyang Liu,
Siwei Zhang,
Liuqing Yang,
Ling Peng,
Shanshan Tang,
Wanlin Li,
Zengchen Liu,
Xichao Zhu,
Tingdan Gong,
Siyu Duan,
Yunyan Tang,
Yao Wang,
Yun Peng,
Rui Li,
Shiyan Feng,
Chuming Chen,
Mengli Cao,
Siran Huang,
Yang Yang,
Fuxiang Wang,
Hongzhou Lu,
Lanlan Wei

Affiliations

Tianyang Liu: Institute for Hepatology, Shenzhen Third People’s Hospital; The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, China
Siwei Zhang: Institute for Hepatology, Shenzhen Third People’s Hospital; The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, China
Liuqing Yang: Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, China
Ling Peng: Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, China
Shanshan Tang: Institute for Hepatology, Shenzhen Third People’s Hospital; The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, China; Institute for Infectious Disease, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China
Wanlin Li: Department of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, China
Zengchen Liu: Institute for Hepatology, Shenzhen Third People’s Hospital; The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, China
Xichao Zhu: Institute for Hepatology, Shenzhen Third People’s Hospital; The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, China
Tingdan Gong: Institute for Hepatology, Shenzhen Third People’s Hospital; The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, China; Department of Pathogenic Microbiology, Harbin Medical University, Harbin, Heilongjiang, China
Siyu Duan: Institute for Hepatology, Shenzhen Third People’s Hospital; The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, China
Yunyan Tang: Institute for Hepatology, Shenzhen Third People’s Hospital; The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, China
Yao Wang: Institute for Hepatology, Shenzhen Third People’s Hospital; The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, China; Department of Basic Medicine, Jiamusi University, Jiamusi, Heilongjiang, China
Yun Peng: Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, China
Rui Li: Institute for Hepatology, Shenzhen Third People’s Hospital; The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, China
Shiyan Feng: Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, China
Chuming Chen: Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, China
Mengli Cao: Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, China
Siran Huang: Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, China
Yang Yang: Institute for Hepatology, Shenzhen Third People’s Hospital; The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, China; Corresponding authors.
Fuxiang Wang: Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, China; Corresponding authors.
Hongzhou Lu: Department of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, China; Corresponding authors.
Lanlan Wei: Department of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, China; Correspondence to: 29 Bulan Road, Nanwan Street, Longgang District, Shenzhen, Guangdong 518112, China.

Journal volume & issue: Vol. 17, no. 12
p. 102586

Abstract

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Objectives: Recent mpox outbreaks highlight diverse transmission modes, with sexual behavior prominent in China's IIb strain. Nevertheless, despite HPV being a common sexually transmitted pathogen, there is a paucity of research into its coexistence and genotype distribution within this patients population. Methods: We conducted a study at the Third People's Hospital of Shenzhen from May to September 2023. We collected information on mpox patients, including their sociodemographic and clinical characteristics. Anal swabs were collected for HPV genotyping. Results: Among 73 MSM mpox cases, HIV positivity was 56.2 % (41/73) and HPV positivity 80.4 % (41/51). Multiple HPV infections were prevalent (56.9 %, 29/51), especially among HIV-positive (93 %, 27/29). HPV16 (29.3 %, 12/41) was the most common high-risk genotype, followed by HPV59 (26.8 %, 10/41), HPV42 (19.5 %, 8/41), HPV6 (14.6 %, 6/41), and HPV54 (14.6 %, 6/41). HPV infection was significantly associated with HIV infection (p = 0.001). Additionally, HIV infection (p = 0.001) and PCR-detected positive sites for mpox (p = 0.047) were associated with high-risk HPV infection. Conclusions: In this study, most of the mpox patients were found to be infected with HPV, mostly with high-risk types and multiple infections. Therefore, it is strongly recommended that mpox-infected individuals intensify HPV-related screening, prevention, and treatment measures.

Published in Journal of Infection and Public Health

ISSN: 1876-0341 (Print); 1876-035X (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Medicine: Public aspects of medicine
Website: https://www.journals.elsevier.com/journal-of-infection-and-public-health

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