Frontiers in Immunology (Mar 2022)
Preclinical Studies on Convalescent Human Immune Plasma-Derived Exosome: Omics and Antiviral Properties to SARS-CoV-2
- Neslihan Pakize Taşlı,
- Zeynep Burçin Gönen,
- Oğuz Kaan Kırbaş,
- Nur Seda Gökdemir,
- Batuhan Turhan Bozkurt,
- Buse Bayrakcı,
- Derya Sağraç,
- Ezgi Taşkan,
- Sevda Demir,
- Nur Ekimci Gürcan,
- Melike Bayındır Bilgiç,
- Ömer Faruk Bayrak,
- Hazel Yetişkin,
- Hazel Yetişkin,
- Büşra Kaplan,
- Büşra Kaplan,
- Shaikh Terkıs Islam Pavel,
- Shaikh Terkıs Islam Pavel,
- Gökçen Dinç,
- Müge Serhatlı,
- Gamze Çakırca,
- Gamze Çakırca,
- Ahmet Eken,
- Ahmet Eken,
- Vedat Aslan,
- Mehmet Yay,
- Musa Karakukcu,
- Ekrem Unal,
- Fethi Gül,
- Kemal Erdem Basaran,
- Kemal Erdem Basaran,
- Yusuf Ozkul,
- Yusuf Ozkul,
- Fikrettin Şahin,
- Olcay Y. Jones,
- Şaban Tekin,
- Şaban Tekin,
- Aykut Özdarendeli,
- Aykut Özdarendeli,
- Mustafa Cetin
Affiliations
- Neslihan Pakize Taşlı
- Faculty of Engineering, Yeditepe University, Istanbul, Turkey
- Zeynep Burçin Gönen
- Oral and Maxillofacial Surgery, Genome and Stem Cell Centre, Erciyes University, Kayseri, Turkey
- Oğuz Kaan Kırbaş
- Faculty of Engineering, Yeditepe University, Istanbul, Turkey
- Nur Seda Gökdemir
- Oral and Maxillofacial Surgery, Genome and Stem Cell Centre, Erciyes University, Kayseri, Turkey
- Batuhan Turhan Bozkurt
- Faculty of Engineering, Yeditepe University, Istanbul, Turkey
- Buse Bayrakcı
- Faculty of Engineering, Yeditepe University, Istanbul, Turkey
- Derya Sağraç
- Faculty of Engineering, Yeditepe University, Istanbul, Turkey
- Ezgi Taşkan
- Faculty of Engineering, Yeditepe University, Istanbul, Turkey
- Sevda Demir
- Faculty of Engineering, Yeditepe University, Istanbul, Turkey
- Nur Ekimci Gürcan
- Faculty of Medicine, Yeditepe University, Istanbul, Turkey
- Melike Bayındır Bilgiç
- Faculty of Medicine, Yeditepe University, Istanbul, Turkey
- Ömer Faruk Bayrak
- Faculty of Medicine, Yeditepe University, Istanbul, Turkey
- Hazel Yetişkin
- Faculty of Medicine, Erciyes University, Kayseri, Turkey
- Hazel Yetişkin
- Vaccine Research and Development Application and Research Center, Erciyes University, Kayseri, Turkey
- Büşra Kaplan
- Faculty of Medicine, Erciyes University, Kayseri, Turkey
- Büşra Kaplan
- Vaccine Research and Development Application and Research Center, Erciyes University, Kayseri, Turkey
- Shaikh Terkıs Islam Pavel
- Faculty of Medicine, Erciyes University, Kayseri, Turkey
- Shaikh Terkıs Islam Pavel
- Vaccine Research and Development Application and Research Center, Erciyes University, Kayseri, Turkey
- Gökçen Dinç
- Faculty of Medicine, Erciyes University, Kayseri, Turkey
- Müge Serhatlı
- The Scientific and Technological Research Council of Turkey (TÜBITAK) Marmara Research Centre Energy Institute, Kocaeli, Turkey
- Gamze Çakırca
- The Scientific and Technological Research Council of Turkey (TÜBITAK) Marmara Research Centre Energy Institute, Kocaeli, Turkey
- Gamze Çakırca
- Department of Molecular Biology and Genetics, Faculty of Science, Gebze Technical University, Kocaeli, Turkey
- Ahmet Eken
- Department of Biology, Faculty of Science, Erciyes University, Kayseri, Turkey
- Ahmet Eken
- Gevher Nesibe Genome and Stem Cell Institute, Erciyes University, Kayseri, Turkey
- Vedat Aslan
- 0Antalya Training and Research Hospital, Antalya, Turkey
- Mehmet Yay
- Faculty of Medicine, Erciyes University, Kayseri, Turkey
- Musa Karakukcu
- Faculty of Medicine, Erciyes University, Kayseri, Turkey
- Ekrem Unal
- Faculty of Medicine, Erciyes University, Kayseri, Turkey
- Fethi Gül
- 1Department of Anesthesiology and Reanimation, School of Medicine, Marmara University, Istanbul, Turkey
- Kemal Erdem Basaran
- Faculty of Medicine, Erciyes University, Kayseri, Turkey
- Kemal Erdem Basaran
- Gevher Nesibe Genome and Stem Cell Institute, Erciyes University, Kayseri, Turkey
- Yusuf Ozkul
- Faculty of Medicine, Erciyes University, Kayseri, Turkey
- Yusuf Ozkul
- Gevher Nesibe Genome and Stem Cell Institute, Erciyes University, Kayseri, Turkey
- Fikrettin Şahin
- Faculty of Engineering, Yeditepe University, Istanbul, Turkey
- Olcay Y. Jones
- 2Division of Rheumatology, Department of Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, United States
- Şaban Tekin
- The Scientific and Technological Research Council of Turkey (TÜBITAK) Marmara Research Centre Energy Institute, Kocaeli, Turkey
- Şaban Tekin
- 3Medical Biology, Department of Basic Medical Sciences, University of Health Sciences, Istanbul, Turkey
- Aykut Özdarendeli
- Faculty of Medicine, Erciyes University, Kayseri, Turkey
- Aykut Özdarendeli
- Vaccine Research and Development Application and Research Center, Erciyes University, Kayseri, Turkey
- Mustafa Cetin
- Faculty of Medicine, Erciyes University, Kayseri, Turkey
- DOI
- https://doi.org/10.3389/fimmu.2022.824378
- Journal volume & issue
-
Vol. 13
Abstract
The scale of the COVID-19 pandemic forced urgent measures for the development of new therapeutics. One of these strategies is the use of convalescent plasma (CP) as a conventional source for passive immunity. Recently, there has been interest in CP-derived exosomes. In this report, we present a structural, biochemical, and biological characterization of our proprietary product, convalescent human immune plasma-derived exosome (ChipEXO), following the guidelines set forth by the Turkish Ministry of Health and the Turkish Red Crescent, the Good Manufacturing Practice, the International Society for Extracellular Vesicles, and the Gene Ontology Consortium. The data support the safety and efficacy of this product against SARS-CoV-2 infections in preclinical models.
Keywords
