Molecular Mechanisms of Ferroptosis and Their Involvement in Acute Kidney Injury

Abstract

Jie Liu,1 Xiaoxia Han,1 Jia Zhou,1 Yufang Leng1,2 1The First School of Clinical Medicine, Lanzhou University, Lanzhou, People’s Republic of China; 2Department of Anesthesiology, The First Hospital of Lanzhou University, Lanzhou, People’s Republic of ChinaCorrespondence: Yufang Leng, Email [email protected]: Ferroptosis is a novel way of regulating cell death, which occurs in a process that is closely linked to intracellular iron metabolism, lipid metabolism, amino acid metabolism, and multiple signaling pathways. The latest research shows that ferroptosis plays a key role in the pathogenesis of acute kidney injury (AKI). Ferroptosis may be an important target for treating AKI caused by various reasons, such as ischemia-reperfusion injury, rhabdomyolysis syndrome, sepsis, and nephrotoxic drugs. This paper provides a review on the regulatory mechanisms of ferroptosis and its role in AKI, which may help to provide new research ideas for the treatment of AKI and future research.Keywords: ferroptosis, iron, lipid peroxidation, molecular mechanism, acute kidney injury

Keywords

• ferroptosis
• iron
• lipid peroxidation
• molecular mechanism
• acute kidney injury