Nature Communications (Jun 2016)

Memory of cell shape biases stochastic fate decision-making despite mitotic rounding

  • Takashi Akanuma,
  • Cong Chen,
  • Tetsuo Sato,
  • Roeland M. H. Merks,
  • Thomas N. Sato

DOI
https://doi.org/10.1038/ncomms11963
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 17

Abstract

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Cell shape influences function but during mitotic cell rounding the original shape is lost. Here the authors show that the cellular eccentricity of progenitor cell biases stochastic fate-decisions using a combination of quantitative live imaging, genetic manipulations and computational simulations.