Frontiers in Nanotechnology (Mar 2022)
Wireless Closed-Loop Optical Regulation System for Seizure Detection and Suppression In Vivo
- Yamin Li,
- Yamin Li,
- Shengwei Xu,
- Shengwei Xu,
- Yang Wang,
- Yang Wang,
- Yiming Duan,
- Yiming Duan,
- Qianli Jia,
- Qianli Jia,
- Jingyu Xie,
- Jingyu Xie,
- Xiaowei Yang,
- Yiding Wang,
- Yiding Wang,
- Yuchuan Dai,
- Yuchuan Dai,
- Gucheng Yang,
- Gucheng Yang,
- Miao Yuan,
- Miao Yuan,
- Xiaoting Wu,
- Xiaoting Wu,
- Yilin Song,
- Yilin Song,
- Mixia Wang,
- Mixia Wang,
- Hongda Chen,
- Hongda Chen,
- Yijun Wang,
- Yijun Wang,
- Xinxia Cai,
- Xinxia Cai,
- Weihua Pei,
- Weihua Pei,
- Weihua Pei
Affiliations
- Yamin Li
- State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing, China
- Yamin Li
- Institute of Semiconductors, University of Chinese Academy of Sciences, Beijing, China
- Shengwei Xu
- Institute of Semiconductors, University of Chinese Academy of Sciences, Beijing, China
- Shengwei Xu
- State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China
- Yang Wang
- State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing, China
- Yang Wang
- Institute of Semiconductors, University of Chinese Academy of Sciences, Beijing, China
- Yiming Duan
- Institute of Semiconductors, University of Chinese Academy of Sciences, Beijing, China
- Yiming Duan
- State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China
- Qianli Jia
- Institute of Semiconductors, University of Chinese Academy of Sciences, Beijing, China
- Qianli Jia
- State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China
- Jingyu Xie
- Institute of Semiconductors, University of Chinese Academy of Sciences, Beijing, China
- Jingyu Xie
- State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China
- Xiaowei Yang
- State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing, China
- Yiding Wang
- Institute of Semiconductors, University of Chinese Academy of Sciences, Beijing, China
- Yiding Wang
- State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China
- Yuchuan Dai
- Institute of Semiconductors, University of Chinese Academy of Sciences, Beijing, China
- Yuchuan Dai
- State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China
- Gucheng Yang
- Institute of Semiconductors, University of Chinese Academy of Sciences, Beijing, China
- Gucheng Yang
- State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China
- Miao Yuan
- State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing, China
- Miao Yuan
- Institute of Semiconductors, University of Chinese Academy of Sciences, Beijing, China
- Xiaoting Wu
- State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing, China
- Xiaoting Wu
- Institute of Semiconductors, University of Chinese Academy of Sciences, Beijing, China
- Yilin Song
- Institute of Semiconductors, University of Chinese Academy of Sciences, Beijing, China
- Yilin Song
- State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China
- Mixia Wang
- Institute of Semiconductors, University of Chinese Academy of Sciences, Beijing, China
- Mixia Wang
- State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China
- Hongda Chen
- State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing, China
- Hongda Chen
- Institute of Semiconductors, University of Chinese Academy of Sciences, Beijing, China
- Yijun Wang
- State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing, China
- Yijun Wang
- Institute of Semiconductors, University of Chinese Academy of Sciences, Beijing, China
- Xinxia Cai
- Institute of Semiconductors, University of Chinese Academy of Sciences, Beijing, China
- Xinxia Cai
- State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing, China
- Weihua Pei
- State Key Laboratory on Integrated Optoelectronics, Institute of Semiconductors, Chinese Academy of Sciences, Beijing, China
- Weihua Pei
- Institute of Semiconductors, University of Chinese Academy of Sciences, Beijing, China
- Weihua Pei
- CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai, China
- DOI
- https://doi.org/10.3389/fnano.2022.829751
- Journal volume & issue
-
Vol. 4
Abstract
There are approximately 50 million people with epilepsy worldwide, even about 25% of whom cannot be effectively controlled by drugs or surgical treatment. A wireless closed-loop system for epilepsy detection and suppression is proposed in this study. The system is composed of an implantable optrode, wireless recording, wireless energy supply, and a control module. The system can monitor brain electrical activity in real time. When seizures are recognized, the optrode will be turned on. The preset photosensitive caged compounds are activated to inhibit the seizure. When seizures are inhibited or end, the optrode is turned off. The method demonstrates a practical wireless closed-loop epilepsy therapy system.
Keywords
