Nature Communications (Mar 2016)
Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia
- Sonja I. Berndt,
- Nicola J. Camp,
- Christine F. Skibola,
- Joseph Vijai,
- Zhaoming Wang,
- Jian Gu,
- Alexandra Nieters,
- Rachel S. Kelly,
- Karin E. Smedby,
- Alain Monnereau,
- Wendy Cozen,
- Angela Cox,
- Sophia S. Wang,
- Qing Lan,
- Lauren R. Teras,
- Moara Machado,
- Meredith Yeager,
- Angela R. Brooks-Wilson,
- Patricia Hartge,
- Mark P. Purdue,
- Brenda M. Birmann,
- Claire M. Vajdic,
- Pierluigi Cocco,
- Yawei Zhang,
- Graham G. Giles,
- Anne Zeleniuch-Jacquotte,
- Charles Lawrence,
- Rebecca Montalvan,
- Laurie Burdett,
- Amy Hutchinson,
- Yuanqing Ye,
- Timothy G. Call,
- Tait D. Shanafelt,
- Anne J. Novak,
- Neil E. Kay,
- Mark Liebow,
- Julie M. Cunningham,
- Cristine Allmer,
- Henrik Hjalgrim,
- Hans-Olov Adami,
- Mads Melbye,
- Bengt Glimelius,
- Ellen T. Chang,
- Martha Glenn,
- Karen Curtin,
- Lisa A. Cannon-Albright,
- W Ryan Diver,
- Brian K. Link,
- George J. Weiner,
- Lucia Conde,
- Paige M. Bracci,
- Jacques Riby,
- Donna K. Arnett,
- Degui Zhi,
- Justin M. Leach,
- Elizabeth A. Holly,
- Rebecca D. Jackson,
- Lesley F. Tinker,
- Yolanda Benavente,
- Núria Sala,
- Delphine Casabonne,
- Nikolaus Becker,
- Paolo Boffetta,
- Paul Brennan,
- Lenka Foretova,
- Marc Maynadie,
- James McKay,
- Anthony Staines,
- Kari G. Chaffee,
- Sara J. Achenbach,
- Celine M. Vachon,
- Lynn R. Goldin,
- Sara S. Strom,
- Jose F. Leis,
- J. Brice Weinberg,
- Neil E. Caporaso,
- Aaron D. Norman,
- Anneclaire J. De Roos,
- Lindsay M. Morton,
- Richard K. Severson,
- Elio Riboli,
- Paolo Vineis,
- Rudolph Kaaks,
- Giovanna Masala,
- Elisabete Weiderpass,
- María- Dolores Chirlaque,
- Roel C. H. Vermeulen,
- Ruth C. Travis,
- Melissa C. Southey,
- Roger L. Milne,
- Demetrius Albanes,
- Jarmo Virtamo,
- Stephanie Weinstein,
- Jacqueline Clavel,
- Tongzhang Zheng,
- Theodore R. Holford,
- Danylo J. Villano,
- Ann Maria,
- John J. Spinelli,
- Randy D. Gascoyne,
- Joseph M. Connors,
- Kimberly A. Bertrand,
- Edward Giovannucci,
- Peter Kraft,
- Anne Kricker,
- Jenny Turner,
- Maria Grazia Ennas,
- Giovanni M. Ferri,
- Lucia Miligi,
- Liming Liang,
- Baoshan Ma,
- Jinyan Huang,
- Simon Crouch,
- Ju-Hyun Park,
- Nilanjan Chatterjee,
- Kari E. North,
- John A. Snowden,
- Josh Wright,
- Joseph F. Fraumeni,
- Kenneth Offit,
- Xifeng Wu,
- Silvia de Sanjose,
- James R. Cerhan,
- Stephen J. Chanock,
- Nathaniel Rothman,
- Susan L. Slager
Affiliations
- Sonja I. Berndt
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Nicola J. Camp
- Division of Hematology and Hematologic Malignancies, Department of Internal Medicine, Huntsman Cancer Institute and University of Utah School of Medicine
- Christine F. Skibola
- Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham
- Joseph Vijai
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Zhaoming Wang
- Division of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute
- Jian Gu
- Department of Epidemiology, MD Anderson Cancer Center
- Alexandra Nieters
- Center for Chronic Immunodeficiency, University Medical Center Freiburg
- Rachel S. Kelly
- Department of Epidemiology, Harvard School of Public Health
- Karin E. Smedby
- Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital
- Alain Monnereau
- Epidemiology of Childhood and Adolescent Cancers Group, INSERM, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS)
- Wendy Cozen
- Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California
- Angela Cox
- Department of Oncology, University of Sheffield
- Sophia S. Wang
- Division of Cancer Etiology, City of Hope Beckman Research Institute
- Qing Lan
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Lauren R. Teras
- Epidemiology Research Program, American Cancer Society
- Moara Machado
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Meredith Yeager
- Division of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute
- Angela R. Brooks-Wilson
- Genome Sciences Centre, BC Cancer Agency
- Patricia Hartge
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Mark P. Purdue
- Ontario Health Study
- Brenda M. Birmann
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
- Claire M. Vajdic
- Centre for Big Data Research in Health, University of New South Wales
- Pierluigi Cocco
- Department of Public Health, Clinical and Molecular Medicine, University of Cagliari
- Yawei Zhang
- Department of Environmental Health Sciences, Yale School of Public Health
- Graham G. Giles
- Cancer Epidemiology Centre, Cancer Council Victoria
- Anne Zeleniuch-Jacquotte
- Department of Population Health, New York University School of Medicine
- Charles Lawrence
- Westat
- Rebecca Montalvan
- Westat
- Laurie Burdett
- Division of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute
- Amy Hutchinson
- Division of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute
- Yuanqing Ye
- Department of Epidemiology, MD Anderson Cancer Center
- Timothy G. Call
- Division of Hematology, Mayo Clinic
- Tait D. Shanafelt
- Department of Medicine, Mayo Clinic
- Anne J. Novak
- Department of Medicine, Mayo Clinic
- Neil E. Kay
- Division of Hematology, Mayo Clinic
- Mark Liebow
- Department of Medicine, Mayo Clinic
- Julie M. Cunningham
- Department of Laboratory Medicine and Pathology, Mayo Clinic
- Cristine Allmer
- Department of Health Sciences Research, Mayo Clinic
- Henrik Hjalgrim
- Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut
- Hans-Olov Adami
- Department of Epidemiology, Harvard School of Public Health
- Mads Melbye
- Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut
- Bengt Glimelius
- Department of Immunology, Genetics and Pathology, Uppsala University
- Ellen T. Chang
- Center for Epidemiology and Computational Biology, Health Sciences, Exponent, Inc.
- Martha Glenn
- Department of Internal Medicine, Huntsman Cancer Institute
- Karen Curtin
- Department of Internal Medicine, University of Utah School of Medicine
- Lisa A. Cannon-Albright
- Department of Internal Medicine, University of Utah School of Medicine
- W Ryan Diver
- Epidemiology Research Program, American Cancer Society
- Brian K. Link
- Department of Internal Medicine, Carver College of Medicine, The University of Iowa
- George J. Weiner
- Department of Internal Medicine, Carver College of Medicine, The University of Iowa
- Lucia Conde
- Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham
- Paige M. Bracci
- Department of Epidemiology and Biostatistics, University of California San Francisco
- Jacques Riby
- Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham
- Donna K. Arnett
- Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham
- Degui Zhi
- Department of Biostatistics, University of Alabama at Birmingham
- Justin M. Leach
- Department of Biostatistics, University of Alabama at Birmingham
- Elizabeth A. Holly
- Department of Epidemiology and Biostatistics, University of California San Francisco
- Rebecca D. Jackson
- Division of Endocrinology, Diabetes and Metabolism, The Ohio State University
- Lesley F. Tinker
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Yolanda Benavente
- Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de Llobregat
- Núria Sala
- Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de Llobregat
- Delphine Casabonne
- Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d’Oncologia, IDIBELL, 08908L’Hospitalet de Llobregat
- Nikolaus Becker
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Paolo Boffetta
- The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Paul Brennan
- International Agency for Research on Cancer (IARC)
- Lenka Foretova
- Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU
- Marc Maynadie
- EA 4184, Registre des Hémopathies Malignes de Côte d’Or, University of Burgundy and Dijon University Hospital
- James McKay
- International Agency for Research on Cancer (IARC)
- Anthony Staines
- School of Nursing and Human Sciences, Dublin City University
- Kari G. Chaffee
- Department of Health Sciences Research, Mayo Clinic
- Sara J. Achenbach
- Department of Health Sciences Research, Mayo Clinic
- Celine M. Vachon
- Department of Health Sciences Research, Mayo Clinic
- Lynn R. Goldin
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Sara S. Strom
- Department of Epidemiology, MD Anderson Cancer Center
- Jose F. Leis
- Division of Hematology/Oncology, Mayo Clinic
- J. Brice Weinberg
- Department of Medicine, Duke University and VA Medical Centers
- Neil E. Caporaso
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Aaron D. Norman
- Department of Health Sciences Research, Mayo Clinic
- Anneclaire J. De Roos
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Lindsay M. Morton
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Richard K. Severson
- Department of Family Medicine and Public Health Sciences, Wayne State University
- Elio Riboli
- School of Public Health, Imperial College London
- Paolo Vineis
- MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London
- Rudolph Kaaks
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Giovanna Masala
- Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO)
- Elisabete Weiderpass
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- María- Dolores Chirlaque
- CIBER de Epidemiología y Salud Pública (CIBERESP)
- Roel C. H. Vermeulen
- Institute for Risk Assessment Sciences, Utrecht University
- Ruth C. Travis
- Cancer Epidemiology Unit, University of Oxford
- Melissa C. Southey
- Department of Pathology, Genetic Epidemiology Laboratory, University of Melbourne
- Roger L. Milne
- Cancer Epidemiology Centre, Cancer Council Victoria
- Demetrius Albanes
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Jarmo Virtamo
- Chronic Disease Prevention Unit, National Institute for Health and Welfare
- Stephanie Weinstein
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Jacqueline Clavel
- Epidemiology of Childhood and Adolescent Cancers Group, INSERM, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS)
- Tongzhang Zheng
- Department of Environmental Health Sciences, Yale School of Public Health
- Theodore R. Holford
- Department of Biostatistics, Yale School of Public Health
- Danylo J. Villano
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Ann Maria
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- John J. Spinelli
- Cancer Control Research, BC Cancer Agency
- Randy D. Gascoyne
- Center for Lymphoid Cancer, BC Cancer Agency
- Joseph M. Connors
- Center for Lymphoid Cancer, BC Cancer Agency
- Kimberly A. Bertrand
- Department of Epidemiology, Harvard School of Public Health
- Edward Giovannucci
- Department of Epidemiology, Harvard School of Public Health
- Peter Kraft
- Department of Epidemiology, Harvard School of Public Health
- Anne Kricker
- Sydney School of Public Health, The University of Sydney
- Jenny Turner
- Faculty of Medicine and Health Sciences, Macquarie University
- Maria Grazia Ennas
- Department of Biomedical Science, University of Cagliari
- Giovanni M. Ferri
- Interdisciplinary Department of Medicine, University of Bari
- Lucia Miligi
- Environmental and Occupational Epidemiology Unit, Cancer Prevention and Research Institute (ISPO)
- Liming Liang
- Department of Epidemiology, Harvard School of Public Health
- Baoshan Ma
- Department of Epidemiology, Harvard School of Public Health
- Jinyan Huang
- Department of Epidemiology, Harvard School of Public Health
- Simon Crouch
- Department of Health Sciences, University of York
- Ju-Hyun Park
- Department of Statistics, Dongguk University
- Nilanjan Chatterjee
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Kari E. North
- Department of Epidemiology, University of North Carolina at Chapel Hill
- John A. Snowden
- Department of Oncology, University of Sheffield
- Josh Wright
- Department of Oncology, University of Sheffield
- Joseph F. Fraumeni
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Kenneth Offit
- Department of Medicine, Memorial Sloan Kettering Cancer Center
- Xifeng Wu
- Department of Epidemiology, MD Anderson Cancer Center
- Silvia de Sanjose
- Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de Llobregat
- James R. Cerhan
- Department of Health Sciences Research, Mayo Clinic
- Stephen J. Chanock
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Nathaniel Rothman
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Susan L. Slager
- Department of Health Sciences Research, Mayo Clinic
- DOI
- https://doi.org/10.1038/ncomms10933
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 9
Abstract
Chronic lymphocytic leukemia is a highly inheritable cancer. Here the authors conduct a metaanalysis of four genome-wide association studies and identify three novel loci located near EOMES, SERPINB6 and LPPassociated with risk of this disease.
