Communications Biology (Jul 2021)

Drug transport kinetics of intravascular triggered drug delivery systems

  • Timo L. M. ten Hagen,
  • Matthew R. Dreher,
  • Sara Zalba,
  • Ann L. B. Seynhaeve,
  • Mohamadreza Amin,
  • Li Li,
  • Dieter Haemmerich

DOI
https://doi.org/10.1038/s42003-021-02428-z
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 17

Abstract

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Ten Hagen et al. developed a computational model to simulate intravascular triggered drug delivery systems (IV-DDS), which they validated using quantitative intravital microscopy in mice. Their model potentially enables the engineering of more efficacious IV-DDS based on parameters that can be quantified by imaging.