Nature Communications (Jun 2017)
CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers
- Smruthi Vijayaraghavan,
- Cansu Karakas,
- Iman Doostan,
- Xian Chen,
- Tuyen Bui,
- Min Yi,
- Akshara S. Raghavendra,
- Yang Zhao,
- Sami I. Bashour,
- Nuhad K. Ibrahim,
- Meghan Karuturi,
- Jing Wang,
- Jeffrey D. Winkler,
- Ravi K. Amaravadi,
- Kelly K. Hunt,
- Debu Tripathy,
- Khandan Keyomarsi
Affiliations
- Smruthi Vijayaraghavan
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Cansu Karakas
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Iman Doostan
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Xian Chen
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Tuyen Bui
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- Min Yi
- Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Akshara S. Raghavendra
- Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center
- Yang Zhao
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Sami I. Bashour
- Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center
- Nuhad K. Ibrahim
- Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center
- Meghan Karuturi
- Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center
- Jing Wang
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Jeffrey D. Winkler
- Department of Chemistry, University of Pennsylvania
- Ravi K. Amaravadi
- Division of Hematology Oncology, Perelman School of Medicine, University of Pennsylvania
- Kelly K. Hunt
- Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Debu Tripathy
- Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center
- Khandan Keyomarsi
- Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/ncomms15916
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 17
Abstract
CDK4/6-Cyclin D pathway is often deregulated in cancer; therefore specific inhibitors have been developed. Here the authors show that treatment with CDK4/6 inhibitors activate autophagy in breast cancer cells; thus, combination of such inhibitors with autophagy inhibitors results in a synergistic effect on tumour growth.
