IMMUNITY AND DYNAMICS OF INFECTIONS IN HERPESVIRUS-CARRYING PREGNANT WOMEN WITH UNDIFFERENTIATED FORMS OF CONNECTIVE TISSUE DYSPLASIA HERPES VIRUSES

Abstract

Abstract. We have studied some immune parameters in pregnant women with undifferentiated forms of connective tissue dysplasia (n = 51), who harboured herpesviruses, i.e., cytomegalovirus and Herpes Simplex virus. A relative insufficiency of CD3+ lymphocytes, along with deficiency of CD4+T cells, and predominance of CD16+ cells (NK cells), and CD20+ cells were revealed, accompanied by increase in IgM and the decrease in IgA and IgG levels. Disturbances of cellular and humoral immunity in such patients were more expressed than in women without undifferentiated forms of connective tissue dysplasia (n = 50), being associated with increased frequency of infection manifesting as inflammatory placental lesion with secondary placental insufficiency and more pessimistic perinatal outcomes. The results obtained justify a need for second preventive measures in pregnant, herpesvirus-carrying women with undifferentiated connective tissue dysplasia. (Med. Immunol., 2011, vol. 13, N 2-3, pp 175-180)

Keywords

• connective tissue displasia
• pregnancy
• herpes simplex virus
• cytomegalovirus
• immunit