Evidence of Clinical and Laboratory Correlation of Itraconazole Resistance in <i>Sporothrix brasiliensis</i> Infection: Case Report

John Verrinder Veasey; Ana Paula Carvalho Reis; Giovanna Azevedo Celestrino; Camila Estacia Silva; Eduarda Souza Santos; Denise Polizel Mendes; Tania Sueli Andrade; Lucas Xavier Bonfietti; Gil Benard; Maria Glória Texeira Sousa

doi:10.3390/microorganisms12112132

Microorganisms (Oct 2024)

Evidence of Clinical and Laboratory Correlation of Itraconazole Resistance in <i>Sporothrix brasiliensis</i> Infection: Case Report

John Verrinder Veasey,
Ana Paula Carvalho Reis,
Giovanna Azevedo Celestrino,
Camila Estacia Silva,
Eduarda Souza Santos,
Denise Polizel Mendes,
Tania Sueli Andrade,
Lucas Xavier Bonfietti,
Gil Benard,
Maria Glória Texeira Sousa

Affiliations

John Verrinder Veasey: School of Medical Sciences, Santa Casa de Sao Paulo, São Paulo 01221010, Brazil
Ana Paula Carvalho Reis: Laboratory of Medical Mycology LIM-53, Clinical Dermatology Division, Hospital das Clínicas FMUSP, Faculdade de Medicina FMUSP, Institute of Tropical Medicine, University of São Paulo, São Paulo 05403000, Brazil
Giovanna Azevedo Celestrino: Laboratory of Medical Mycology LIM-53, Clinical Dermatology Division, Hospital das Clínicas FMUSP, Faculdade de Medicina FMUSP, Institute of Tropical Medicine, University of São Paulo, São Paulo 05403000, Brazil
Camila Estacia Silva: Laboratory of Medical Mycology LIM-53, Clinical Dermatology Division, Hospital das Clínicas FMUSP, Faculdade de Medicina FMUSP, Institute of Tropical Medicine, University of São Paulo, São Paulo 05403000, Brazil
Eduarda Souza Santos: Laboratory of Medical Mycology LIM-53, Clinical Dermatology Division, Hospital das Clínicas FMUSP, Faculdade de Medicina FMUSP, Institute of Tropical Medicine, University of São Paulo, São Paulo 05403000, Brazil
Denise Polizel Mendes: Laboratory of Medical Mycology LIM-53, Clinical Dermatology Division, Hospital das Clínicas FMUSP, Faculdade de Medicina FMUSP, Institute of Tropical Medicine, University of São Paulo, São Paulo 05403000, Brazil
Tania Sueli Andrade: Department of Culture Collection, Adolfo Lutz Institute, Secretary of Health, Sao Paulo 01246000, Brazil
Lucas Xavier Bonfietti: Health Department, Mycology Nucleus of Instituto Adolfo Lutz, São Paulo 01246000, Brazil
Gil Benard: Laboratory of Medical Mycology LIM-53, Clinical Dermatology Division, Hospital das Clínicas FMUSP, Faculdade de Medicina FMUSP, Institute of Tropical Medicine, University of São Paulo, São Paulo 05403000, Brazil
Maria Glória Texeira Sousa: Laboratory of Medical Mycology LIM-53, Clinical Dermatology Division, Hospital das Clínicas FMUSP, Faculdade de Medicina FMUSP, Institute of Tropical Medicine, University of São Paulo, São Paulo 05403000, Brazil

DOI: https://doi.org/10.3390/microorganisms12112132
Journal volume & issue: Vol. 12, no. 11
p. 2132

Abstract

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Sporotrichosis is a subcutaneous infection caused by fungi from the genus Sporothrix, among which Sporothrix brasiliensis displays high virulence and transmissibility. So far, classical antifungal agents have been efficient against S. brasiliensis, but here we describe the first case of therapeutic failure and a high minimum inhibitory concentration (MIC) in relation to itraconazole.

Published in Microorganisms

ISSN: 2076-2607 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.mdpi.com/journal/microorganisms

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