Nature Communications (Feb 2018)
FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming
- Ivo S. Hansen,
- Lisette Krabbendam,
- Jochem H. Bernink,
- Fabricio Loayza-Puch,
- Willianne Hoepel,
- Johan A. van Burgsteden,
- Elsa C. Kuijper,
- Christianne J. Buskens,
- Willem A. Bemelman,
- Sebastiaan A. J. Zaat,
- Reuven Agami,
- Gestur Vidarsson,
- Gijs R. van den Brink,
- Esther C. de Jong,
- Manon E. Wildenberg,
- Dominique L. P. Baeten,
- Bart Everts,
- Jeroen den Dunnen
Affiliations
- Ivo S. Hansen
- Amsterdam Rheumatology and Immunology Centre, Department of Clinical Immunology and Rheumatology, Academic Medical Centre, University of Amsterdam
- Lisette Krabbendam
- Department of Experimental Immunology, Academic Medical Centre, University of Amsterdam
- Jochem H. Bernink
- Department of Experimental Immunology, Academic Medical Centre, University of Amsterdam
- Fabricio Loayza-Puch
- Division of Oncogenomics, Netherlands Cancer Institute
- Willianne Hoepel
- Amsterdam Rheumatology and Immunology Centre, Department of Clinical Immunology and Rheumatology, Academic Medical Centre, University of Amsterdam
- Johan A. van Burgsteden
- Amsterdam Rheumatology and Immunology Centre, Department of Clinical Immunology and Rheumatology, Academic Medical Centre, University of Amsterdam
- Elsa C. Kuijper
- Department of Parasitology, Leiden University Medical Centre, University of Leiden
- Christianne J. Buskens
- Department of Surgery, Academic Medical Centre, University of Amsterdam
- Willem A. Bemelman
- Department of Surgery, Academic Medical Centre, University of Amsterdam
- Sebastiaan A. J. Zaat
- Department of Medical Microbiology, Academic Medical Centre, University of Amsterdam
- Reuven Agami
- Division of Oncogenomics, Netherlands Cancer Institute
- Gestur Vidarsson
- Department of Experimental Immunohematology, Sanquin Research, University of Amsterdam
- Gijs R. van den Brink
- Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Centre, University of Amsterdam
- Esther C. de Jong
- Department of Experimental Immunology, Academic Medical Centre, University of Amsterdam
- Manon E. Wildenberg
- Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Centre, University of Amsterdam
- Dominique L. P. Baeten
- Amsterdam Rheumatology and Immunology Centre, Department of Clinical Immunology and Rheumatology, Academic Medical Centre, University of Amsterdam
- Bart Everts
- Department of Parasitology, Leiden University Medical Centre, University of Leiden
- Jeroen den Dunnen
- Amsterdam Rheumatology and Immunology Centre, Department of Clinical Immunology and Rheumatology, Academic Medical Centre, University of Amsterdam
- DOI
- https://doi.org/10.1038/s41467-018-03318-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Dendritic cells (DC) are important for maintaining immune homeostasis in the gut, but how they promote intestinal inflammation upon bacterial infection is still unclear. Here the authors show that IgA immune complexes induce proinflammatory cytokine production by metabolic reprogramming of otherwise tolerogenic human CD103+ DCs.
