Tropical Medicine and Infectious Disease (Sep 2022)

The Characteristics and Patterns of Drug-Resistant Pulmonary Tuberculosis in Eastern India

  • Vishal Prakash Giri,
  • Om Prakash Giri,
  • Pooja Tripathi Pandey,
  • Kripa Nath Mishra,
  • Ram Shanker Prasad,
  • Prabhat Kumar Lal,
  • Rana Pratap,
  • Nishant Nikhil,
  • Abu Sufian,
  • Reyaz Ahmad,
  • Shubhra Kanodia

DOI
https://doi.org/10.3390/tropicalmed7090244
Journal volume & issue
Vol. 7, no. 9
p. 244

Abstract

Read online

Background: Drug-resistant tuberculosis is a major public health problem throughout the world and accounts for substantial morbidity and mortality rates in India, too. Early diagnosis is the corner stone of tuberculosis treatment. State-level and cluster-wise variations in drug resistance is a possibility and should be regularly checked in from time to time. Materials and Methods: The present prospective cohort study (January 2019 to May 2022) was conducted in Darbhanga Medical College and Hospital on drug-resistant pulmonary tuberculosis patients. Sputum specimens were collected from designated centers. Rapid molecular drug-resistance testing (genotypic tests) and growth-based drug-susceptibility testing (DST) (phenotypic tests) were performed in the National Tuberculosis Elimination Program certified Laboratory. Results: A total of 268 patients with drug-resistant pulmonary tuberculosis were included in the study group. The treatment outcomes revealed as cured in 100 (37.31%); treatment completed in 43 (16.04%); died in 56 (20.89%); treatment failed in 22 (8.21%); loss of follow up in 34 (12.69%); and transferred out in 13 (4.85%) drug-resistant pulmonary tuberculosis patients. Adverse events were recorded in 199 (74.25%) of the drug-resistant pulmonary tuberculosis patients. Conclusions: Drug-resistant pulmonary tuberculosis patients are a matter of concern and need to be addressed.

Keywords