p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis

Talha Anwar; Caroline Arellano-Garcia; James Ropa; Yu-Chih Chen; Hong Sun Kim; Euisik Yoon; Sierrah Grigsby; Venkatesha Basrur; Alexey I. Nesvizhskii; Andrew Muntean; Maria E. Gonzalez; Kelley M. Kidwell; Zaneta Nikolovska-Coleska; Celina G. Kleer

doi:10.1038/s41467-018-05078-8

Nature Communications (Jul 2018)

p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis

Talha Anwar,
Caroline Arellano-Garcia,
James Ropa,
Yu-Chih Chen,
Hong Sun Kim,
Euisik Yoon,
Sierrah Grigsby,
Venkatesha Basrur,
Alexey I. Nesvizhskii,
Andrew Muntean,
Maria E. Gonzalez,
Kelley M. Kidwell,
Zaneta Nikolovska-Coleska,
Celina G. Kleer

Affiliations

Talha Anwar: Department of Pathology, University of Michigan Medical School
Caroline Arellano-Garcia: Michigan Post-baccalaureate Research Education Program, University of Michigan
James Ropa: Department of Pathology, University of Michigan Medical School
Yu-Chih Chen: Rogel Cancer Center, University of Michigan
Hong Sun Kim: Department of Pathology, University of Michigan Medical School
Euisik Yoon: Department of Electrical Engineering and Computer Science, University of Michigan
Sierrah Grigsby: Department of Pathology, University of Michigan Medical School
Venkatesha Basrur: Department of Pathology, University of Michigan Medical School
Alexey I. Nesvizhskii: Department of Pathology, University of Michigan Medical School
Andrew Muntean: Department of Pathology, University of Michigan Medical School
Maria E. Gonzalez: Department of Pathology, University of Michigan Medical School
Kelley M. Kidwell: Department of Biostatistics, University of Michigan
Zaneta Nikolovska-Coleska: Department of Pathology, University of Michigan Medical School
Celina G. Kleer: Department of Pathology, University of Michigan Medical School

DOI: https://doi.org/10.1038/s41467-018-05078-8
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Polycomb group protein EZH2 is overexpressed in ER- breast cancer, promoting metastasis. Here, the authors show that independent of the polycomb group, phosphorylation of EZH2 at T367 by p38 promotes cytoplasmic localization of EZH2, binding to vinculin and other regulators of cell migration and invasion.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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