The emerging roles of PHOSPHO1 and its regulated phospholipid homeostasis in metabolic disorders

Yi Liu; Yingting Wu; Mengxi Jiang; Mengxi Jiang

doi:10.3389/fphys.2022.935195

Frontiers in Physiology (Jul 2022)

The emerging roles of PHOSPHO1 and its regulated phospholipid homeostasis in metabolic disorders

Yi Liu,
Yingting Wu,
Mengxi Jiang,
Mengxi Jiang

Affiliations

Yi Liu: Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China
Yingting Wu: Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China
Mengxi Jiang: Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China
Mengxi Jiang: Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China

DOI: https://doi.org/10.3389/fphys.2022.935195
Journal volume & issue: Vol. 13

Abstract

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Emerging evidence suggests that phosphoethanolamine/phosphocholine phosphatase 1 (PHOSPHO1), a specific phosphoethanolamine and phosphocholine phosphatase, is involved in energy metabolism. In this review, we describe the structure and regulation of PHOSPHO1, as well as current knowledge about the role of PHOSPHO1 and its related phospholipid metabolites in regulating energy metabolism. We also examine mechanistic evidence of PHOSPHO1- and phospholipid-mediated regulation of mitochondrial and lipid droplets functions in the context of metabolic homeostasis, which could be potentially targeted for treating metabolic disorders.

Published in Frontiers in Physiology

ISSN: 1664-042X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Physiology
Website: https://www.frontiersin.org/journals/physiology

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