Rapid one-step 18F-radiolabeling of biomolecules in aqueous media by organophosphine fluoride acceptors

Huawei Hong; Lei Zhang; Fang Xie; Rongqiang Zhuang; Donglang Jiang; Huanhuan Liu; Jindian Li; Hongzhang Yang; Xianzhong Zhang; Liming Nie; Zijing Li

doi:10.1038/s41467-019-08953-0

Nature Communications (Mar 2019)

Rapid one-step 18F-radiolabeling of biomolecules in aqueous media by organophosphine fluoride acceptors

Huawei Hong,
Lei Zhang,
Fang Xie,
Rongqiang Zhuang,
Donglang Jiang,
Huanhuan Liu,
Jindian Li,
Hongzhang Yang,
Xianzhong Zhang,
Liming Nie,
Zijing Li

Affiliations

Huawei Hong: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
Lei Zhang: Tianjin Engineering Technology Center of Chemical Wastewater Source Reduction and Recycling, School of Science, Tianjin Chengjian University
Fang Xie: PET center, Huashan Hospital, Fudan University
Rongqiang Zhuang: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
Donglang Jiang: PET center, Huashan Hospital, Fudan University
Huanhuan Liu: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
Jindian Li: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
Hongzhang Yang: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
Xianzhong Zhang: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
Liming Nie: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
Zijing Li: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University

DOI: https://doi.org/10.1038/s41467-019-08953-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 7

Abstract

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The synthesis of 18F-labeled positron emission tomography (PET) tracers is difficult and typically requires anhydrous conditions. Here, the authors developed organophosphine precursors that allow for quick, high-yield synthesis of 18F-labeled probes in either organic solvents or aqueous media.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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