Lung India (Jan 2022)

Role of mepolizumab in severe allergic asthma with vocal cord polyp

  • Azmat Karim,
  • Mohammd Shameem,
  • Abdul Allam Khan

DOI
https://doi.org/10.4103/lungindia.lungindia_272_22
Journal volume & issue
Vol. 39, no. 6
pp. 578 – 580

Abstract

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Interleukin (IL)-5 plays an important role in development, recruitment, and survival of eosinophils, thereby causing debilitating signs and symptoms associated with severe eosinophilic asthma. Mepolizumab is a humanized monoclonal antibody (mAb) against IL-5 which selectively inhibits eosinophilic inflammation and reduces the amount of eosinophils. This reduction is seen in both sputum and blood, resulting in a reduction in exacerbations and in time the need for using systemic steroids. The role of mepolizumab and its effect is still not fully known as there are less real-life studies available. We herewith present a case of severe eosinophilic asthma with vocal polyp managed by mepolizumab.

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