Open Chemistry (Sep 2023)
Antidiabetic, antioxidant and cytotoxicity activities of ortho- and para-substituted Schiff bases derived from metformin hydrochloride: Validation by molecular docking and in silico ADME studies
- Al-Qadsy Inas,
- Saeed Waseem Sharaf,
- Al-Odayni Abdel-Basit,
- Alrabie Ali,
- Al-Faqeeh Lena Ahmed Saleh,
- Al-Adhreai Arwa,
- Al-Owais Ahmad Abdulaziz,
- Semlali Abdelhabib,
- Farooqui Mazahar
Affiliations
- Al-Qadsy Inas
- Chemistry Department, Maulana Azad College of Arts, Science and Commerce, Aurangabad431001, India
- Saeed Waseem Sharaf
- Department of Restorative Dental Sciences, College of Dentistry, King Saud University, P.O. Box 60169, Riyadh 11545, Saudi Arabia
- Al-Odayni Abdel-Basit
- Department of Restorative Dental Sciences, College of Dentistry, King Saud University, P.O. Box 60169, Riyadh 11545, Saudi Arabia
- Alrabie Ali
- Chemistry Department, Maulana Azad College of Arts, Science and Commerce, Aurangabad431001, India
- Al-Faqeeh Lena Ahmed Saleh
- Microbiology Department, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad431004, India
- Al-Adhreai Arwa
- Chemistry Department, Maulana Azad College of Arts, Science and Commerce, Aurangabad431001, India
- Al-Owais Ahmad Abdulaziz
- Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
- Semlali Abdelhabib
- Groupe de Recherche en Écologie Buccale, Faculté de Médecin Dentaire, Université Laval, Quebec, QC G1V 0A6, Canada
- Farooqui Mazahar
- Chemistry Department, Maulana Azad College of Arts, Science and Commerce, Aurangabad431001, India
- DOI
- https://doi.org/10.1515/chem-2023-0125
- Journal volume & issue
-
Vol. 21,
no. 1
pp. 47 – 59
Abstract
No abstracts available.Keywords
- schiff bases of metformin hydrochloride
- 2,2-diphenyl-1-picrylhydrazyl (dpph) radical
- alpha-amylase
- sucrase enzymes
- antidiabetic
- cytotoxicity assay
- docking study
- swissadme properties