Nature Communications (Feb 2023)
Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis
- Kosaku Okuda,
- Kengo Nakahara,
- Akihiro Ito,
- Yuta Iijima,
- Ryosuke Nomura,
- Ashutosh Kumar,
- Kana Fujikawa,
- Kazuya Adachi,
- Yuki Shimada,
- Satoshi Fujio,
- Reina Yamamoto,
- Nobumasa Takasugi,
- Kunishige Onuma,
- Mitsuhiko Osaki,
- Futoshi Okada,
- Taichi Ukegawa,
- Yasuo Takeuchi,
- Norihisa Yasui,
- Atsuko Yamashita,
- Hiroyuki Marusawa,
- Yosuke Matsushita,
- Toyomasa Katagiri,
- Takahiro Shibata,
- Koji Uchida,
- Sheng-Yong Niu,
- Nhi B. Lang,
- Tomohiro Nakamura,
- Kam Y. J. Zhang,
- Stuart A. Lipton,
- Takashi Uehara
Affiliations
- Kosaku Okuda
- Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
- Kengo Nakahara
- Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
- Akihiro Ito
- Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science
- Yuta Iijima
- Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
- Ryosuke Nomura
- Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
- Ashutosh Kumar
- Laboratory for Structural Bioinformatics, Center for Biosystems Dynamics Research, RIKEN
- Kana Fujikawa
- Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
- Kazuya Adachi
- Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
- Yuki Shimada
- Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
- Satoshi Fujio
- Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
- Reina Yamamoto
- Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
- Nobumasa Takasugi
- Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
- Kunishige Onuma
- Division of Experimental Pathology, Faculty of Medicine, Tottori University
- Mitsuhiko Osaki
- Division of Experimental Pathology, Faculty of Medicine, Tottori University
- Futoshi Okada
- Division of Experimental Pathology, Faculty of Medicine, Tottori University
- Taichi Ukegawa
- Department of Synthetic and Medicinal Chemistry, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
- Yasuo Takeuchi
- Department of Synthetic and Medicinal Chemistry, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
- Norihisa Yasui
- Laboratory of Structural Biology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
- Atsuko Yamashita
- Laboratory of Structural Biology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
- Hiroyuki Marusawa
- Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University
- Yosuke Matsushita
- Division of Genome Medicine, Institute of Advanced Medical Sciences, Tokushima University, Tokushima
- Toyomasa Katagiri
- Division of Genome Medicine, Institute of Advanced Medical Sciences, Tokushima University, Tokushima
- Takahiro Shibata
- Graduate School of Bioagricultural Sciences, Nagoya University
- Koji Uchida
- Laboratory of Food Chemistry, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
- Sheng-Yong Niu
- Broad Institute of MIT and Harvard
- Nhi B. Lang
- Neurodegeneration New Medicines Center, and Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute
- Tomohiro Nakamura
- Neurodegeneration New Medicines Center, and Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute
- Kam Y. J. Zhang
- Laboratory for Structural Bioinformatics, Center for Biosystems Dynamics Research, RIKEN
- Stuart A. Lipton
- Neurodegeneration New Medicines Center, and Departments of Molecular Medicine and Neuroscience, The Scripps Research Institute
- Takashi Uehara
- Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
- DOI
- https://doi.org/10.1038/s41467-023-36232-6
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 16
Abstract
Here the authors demonstrate that de novo DNA methylation mediated by DNMT3B is regulated by nitric oxide (NO). They also isolate a unique modulator (DBIC) that inhibits S-nitrosylation of DNMT3B, which mitigates cell proliferation and tumorigenic conversion in vivo.
