Indian Journal of Rheumatology (Jan 2023)

Immune-mediated necrotizing myositis with hydroxy-3-methyl-glutaryl-coenzyme A reductase antibody positivity in MSA-negative and statin-naive profile

  • Kothapalli Nagamounika,
  • Josna Joseph,
  • R Hemanth Kumar,
  • John Mathew

DOI
https://doi.org/10.4103/injr.injr_82_22
Journal volume & issue
Vol. 18, no. 2
pp. 166 – 169

Abstract

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Statin-naïve immune-mediated necrotizing myopathy (IMNM) is a rare disease entity, the diagnosis of which is complicated in the absence of a reliable biomarker. In this context, this case, which is the first one reported from a tertiary care center in South India, is unique. The presence of hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) antibody supplements the clinical diagnosis, specifically in the serological absence of myositis-specific antibodies. A comprehensive diagnostic approach including HMGCR antibody positivity is advisable in IMNM.

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