Cohort profile: Worldwide Collaboration on OsteoArthritis prediCtion for the Hip (World COACH) – an international consortium of prospective cohort studies with individual participant data on hip osteoarthritis
Sita M A Bierma-Zeinstra,
Stefan Kluzek,
David Felson,
Graeme Jones,
Rintje Agricola,
Nigel K Arden,
Joshua Heerey,
Andrea B Mosler,
Flavia Cicuttini,
Jos Runhaar,
M Nevitt,
Nancy E Lane,
John A Lynch,
Harrie Weinans,
Timothy F Cootes,
Kay Crossley,
Cindy G Boer,
Willem Paul Gielis,
Edwin Oei,
Michiel M A van Buuren,
Noortje S Riedstra,
Myrthe A van den Berg,
Fleur D E M Boel,
Harbeer Ahedi,
Vahid Arbabi,
Claudia Lindner,
J Van Meurs,
Amanda E Nelson,
Jinchi Tang
Affiliations
Sita M A Bierma-Zeinstra
Department of General Practice, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands
Stefan Kluzek
Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford Nuffield, Oxford, Oxfordshire, UK
David Felson
Boston University School of Medicine, Boston, Massachusetts, USA
Graeme Jones
Institute for Medical Research, University of Tasmania Menzies, Hobart, Tasmania, Australia
Rintje Agricola
Department of Orthopaedics and Sports Medicine, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands
Nigel K Arden
Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford Nuffield, Oxford, Oxfordshire, UK
Joshua Heerey
La Trobe Sport and Exercise Medicine Research Centre, La Trobe University School of Allied Health Human Services and Sport, Melbourne, Victoria, Australia
Andrea B Mosler
La Trobe Sport and Exercise Medicine Research Centre, La Trobe University School of Allied Health Human Services and Sport, Melbourne, Victoria, Australia
Flavia Cicuttini
Department of Epidemiology and Preventative Medicine, Monash University, Melbourne, Victoria, Australia
Jos Runhaar
Department of General Practice, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands
M Nevitt
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA
Nancy E Lane
Department of Medicine, University of California Davis School of Medicine, Sacramento, California, USA
John A Lynch
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA
Harrie Weinans
Department of Orthopedics, UMC Utrecht, Utrecht, Netherlands
Timothy F Cootes
Centre for Imaging Sciences, The University of Manchester, Manchester, UK
Kay Crossley
La Trobe Sport and Exercise Medicine Research Centre, La Trobe University School of Allied Health Human Services and Sport, Melbourne, Victoria, Australia
Cindy G Boer
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands
Willem Paul Gielis
Department of Orthopedics, UMC Utrecht, Utrecht, Netherlands
Edwin Oei
Department of Radiology & Nuclear Medicine, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands
Michiel M A van Buuren
Department of Orthopaedics and Sports Medicine, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands
Noortje S Riedstra
Department of Orthopaedics and Sports Medicine, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands
Myrthe A van den Berg
Department of Orthopaedics and Sports Medicine, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands
Fleur D E M Boel
Department of Orthopaedics and Sports Medicine, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands
Harbeer Ahedi
Institute for Medical Research, University of Tasmania Menzies, Hobart, Tasmania, Australia
Vahid Arbabi
Department of Orthopedics, UMC Utrecht, Utrecht, Netherlands
Claudia Lindner
Centre for Imaging Sciences, The University of Manchester, Manchester, UK
J Van Meurs
Department of Orthopaedics and Sports Medicine, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands
Amanda E Nelson
Thurston Arthritis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Jinchi Tang
Department of Orthopaedics and Sports Medicine, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands
Purpose Hip osteoarthritis (OA) is a major cause of pain and disability worldwide. Lack of effective therapies may reflect poor knowledge on its aetiology and risk factors, and result in the management of end-stage hip OA with costly joint replacement. The Worldwide Collaboration on OsteoArthritis prediCtion for the Hip (World COACH) consortium was established to pool and harmonise individual participant data from prospective cohort studies. The consortium aims to better understand determinants and risk factors for the development and progression of hip OA, to optimise and automate methods for (imaging) analysis, and to develop a personalised prediction model for hip OA.Participants World COACH aimed to include participants of prospective cohort studies with ≥200 participants, that have hip imaging data available from at least 2 time points at least 4 years apart. All individual participant data, including clinical data, imaging (data), biochemical markers, questionnaires and genetic data, were collected and pooled into a single, individual-level database.Findings to date World COACH currently consists of 9 cohorts, with 38 021 participants aged 18–80 years at baseline. Overall, 71% of the participants were women and mean baseline age was 65.3±8.6 years. Over 34 000 participants had baseline pelvic radiographs available, and over 22 000 had an additional pelvic radiograph after 8–12 years of follow-up. Even longer radiographic follow-up (15–25 years) is available for over 6000 of these participants.Future plans The World COACH consortium offers unique opportunities for studies on the relationship between determinants/risk factors and the development or progression of hip OA, by using harmonised data on clinical findings, imaging, biomarkers, genetics and lifestyle. This provides a unique opportunity to develop a personalised hip OA risk prediction model and to optimise methods for imaging analysis of the hip.
