TRPM7 is an essential regulator for volume-sensitive outwardly rectifying anion channel

Tomohiro Numata; Kaori Sato-Numata; Meredith C. Hermosura; Yasuo Mori; Yasunobu Okada

doi:10.1038/s42003-021-02127-9

Communications Biology (May 2021)

TRPM7 is an essential regulator for volume-sensitive outwardly rectifying anion channel

Tomohiro Numata,
Kaori Sato-Numata,
Meredith C. Hermosura,
Yasuo Mori,
Yasunobu Okada

Affiliations

Tomohiro Numata: Department of Physiology, Graduate School of Medical Sciences, Fukuoka University
Kaori Sato-Numata: Department of Physiology, Graduate School of Medical Sciences, Fukuoka University
Meredith C. Hermosura: John A. Burns School of Medicine
Yasuo Mori: Laboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University
Yasunobu Okada: National Institute for Physiological Sciences

DOI: https://doi.org/10.1038/s42003-021-02127-9
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 14

Abstract

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Numata et al examine whether the TRPM7 ion channel plays a role in the activation of volume-sensitive outwardly rectifying Cl− channels (VSOR) using human and chicken cell lines. By genetically-manipulating the expression of TRPM7 and performing electrophysiology, they demonstrate that TRPM7 is an essential regulator of VSOR activity.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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