PLoS ONE (Jan 2023)

Impact of height difference between coronary ostium and location of intracoronary pressure sensor on fractional flow reserve measurements.

  • Moon-Seung Soh,
  • Hangyul Kim,
  • Min Gyu Kang,
  • Hyo Jin Lee,
  • Seung Do Lee,
  • Seok-Jae Hwang,
  • Jin-Yong Hwang,
  • Kyehwan Kim,
  • Jeong-Rang Park,
  • Hye-Ree Kim,
  • Seung-Jea Tahk,
  • Myeong-Ho Yoon,
  • Hong-Seok Lim,
  • Jin-Sin Koh

DOI
https://doi.org/10.1371/journal.pone.0289646
Journal volume & issue
Vol. 18, no. 8
p. e0289646

Abstract

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BackgroundDuring fractional flow reserve (FFR) measurements, distal coronary pressure (Pd) can be influenced by hydrostatic pressure changes resulting from the height difference (HD) between the coronary ostium and the location of the distal pressure sensor.AimsWe investigated the effect of aortocoronary HD on the FFR measurements in each coronary artery.MethodsIn this retrospective cohort study, we analyzed 257 patients who underwent FFR measurements and coronary computed tomography (CCTA) within a year. Using CCTA, we measured HD as the vertical distance between the coronary ostium and a matched point of the distal coronary pressure sensor identified on coronary angiography.ResultsThe location of the Pd sensor was higher than the coronary ostium in the left anterior descending artery (LAD) (-4.64 ± 1.15 cm) and lower than the coronary ostium in the left circumflex artery (LCX) (2.54 ± 1.05 cm) and right coronary artery (RCA) (2.03 ± 1.28 cm). The corrected FFR values by HD were higher in the LAD (0.78 ± 0.09 to 0.82 ± 0.09, PConclusionHD between the coronary ostium and the distal coronary pressure sensor may affect FFR measurements and FFR-guided treatment decisions for coronary artery disease.